Danby, S.G. orcid.org/0000-0001-7363-140X, Andrew, P.V., Taylor, R.N. et al. (8 more authors) (2022) Different types of emollient cream exhibit diverse physiological effects on the skin barrier in adults with atopic dermatitis. Clinical and Experimental Dermatology, 47 (6). pp. 1154-1164. ISSN 0307-6938
Abstract
Background
Skin barrier dysfunction is a hallmark of Atopic Dermatitis (AD). Despite widespread use, the role of moisturisers in AD development and progression remains unclear.
Objective
To compare the barrier-strengthening properties of a new moisturiser, containing urea and glycerol, to a glycerol-containing moisturiser, a simple paraffin cream (no humectant), and no treatment,
Methods
An observer-blind prospective phase 2 within-subject multilateral single-centre randomised controlled trial in adults with AD (Clinical Trials #NCT03901144). The intervention involved 4-weeks treatment, twice daily, with the 3 products applied to one of 4 areas on the forearms (includes control, randomised allocation). Skin properties (dryness, trans-epidermal water loss [TEWL], hydration and natural moisturising factor [NMF] levels) were assessed before, during and after treatment. The primary outcome was skin sensitivity to the irritant sodium lauryl sulphate (SLS) after treatment.
Results
49 patients were randomised, completed treatment and included in the analysis. The urea/glycerol cream significantly reduced the response to SLS compared to control (-9.0g/m2/h [95%CI -12.562, -5.489] TEWL), paraffin cream (-9.0g/m2/h [-12.602, -5.440] TEWL) and glycerol cream (-4.2g/m2/h [7.760, -0.629] TEWL). Skin moisturisation improved at sites treated with urea/glycerol cream compared to control and paraffin cream, and accompanied by concordant changes in dryness and NMF levels. Subgroup analysis suggested FLG-dependent enhancement of treatment effects.
Conclusion
The urea/glycerol cream strengthened the skin barrier through a mechanism involving increased NMF levels in the skin, and imparted protection from SLS-induced irritation. By helping correct a major pathophysiological process, the urea/glycerol cream has the potential to improve the long-term control of AD.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2022 The Authors. Clinical and Experimental Dermatology published by John Wiley & Sons Ltd on behalf of British Association of Dermatologists. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, (http://creativecommons.org/licenses/by-nc-nd/4.0/) which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Sheffield Teaching Hospitals |
Funding Information: | Funder Grant number PERRIGO NORDIC nan |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 07 Mar 2022 18:21 |
Last Modified: | 02 Feb 2023 15:41 |
Status: | Published |
Publisher: | Wiley |
Refereed: | Yes |
Identification Number: | 10.1111/ced.15141 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:183885 |
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