Clarke, Aimee K., Rossi-Ashton, James A., Taylor, Richard J.K. orcid.org/0000-0002-5880-2490 et al. (1 more author) (2020) Synthesis of polycyclic scaffolds via a gold-catalysed dearomative cyclisation cascade. Tetrahedron. 131392. ISSN 0040-4020
Abstract
Polycyclic scaffolds found in akuammiline alkaloid natural products can be synthesised from ynone-tethered indoles, via a gold(I)-catalysed dearomative cyclisation cascade sequence. The ynone starting materials are themselves made via a two-step modular synthesis from simple tryptamine and tryptophol derivatives.
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Copyright, Publisher and Additional Information: | © Elsevier B. V., 2020. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. | ||||
Keywords: | Akuammiline alkaloids, Cascade reactions, Dearomatisation, Indole, Ynones | ||||
Dates: |
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Institution: | The University of York | ||||
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) | ||||
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Depositing User: | Pure (York) | ||||
Date Deposited: | 28 Jul 2020 13:40 | ||||
Last Modified: | 07 Dec 2022 14:52 | ||||
Published Version: | https://doi.org/10.1016/j.tet.2020.131392 | ||||
Status: | Published | ||||
Refereed: | Yes | ||||
Identification Number: | https://doi.org/10.1016/j.tet.2020.131392 | ||||
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Description: ©Tetrahedron C2 ynone racemic version 12 REVISION FINAL
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