Peckham, D orcid.org/0000-0001-7723-1868, McDermott, MF orcid.org/0000-0002-1015-0745, Savic, S orcid.org/0000-0001-7910-0554 et al. (1 more author) (2020) COVID-19 meets Cystic Fibrosis: for better or worse? Genes & Immunity, 21 (4). pp. 260-262. ISSN 1466-4879
Abstract
Cystic fibrosis (CF) is one of the most common autosomal recessive life-limiting conditions affecting Caucasians. The resulting defect in the cystic fibrosis transmembrane conductance regulator protein (CFTR) results in defective chloride and bicarbonate secretion, as well as dysregulation of epithelial sodium channels (ENaC). These changes bring about defective mucociliary clearance, reduced airway surface liquid and an exaggerated proinflammatory response driven, in part, by infection. In this short article we explore the overlap in the pathophysiology of CF and COVID-19 infection and discuss how understanding the interaction between both diseases may shed light on future treatments.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © The Author(s), under exclusive licence to Springer Nature Limited 2020. This is an author produced version of a brief communication published in Genes & Immunity. Uploaded in accordance with the publisher's self-archiving policy. |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Institute of Rheumatology & Musculoskeletal Medicine (LIRMM) (Leeds) > Clinical Musculoskeletal Medicine (LIRMM) (Leeds) The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Institute of Rheumatology & Musculoskeletal Medicine (LIRMM) (Leeds) > Inflammatory Arthritis (Leeds) |
Funding Information: | Funder Grant number Cystic Fibrosis Trust SRC009 |
Depositing User: | Symplectic Publications |
Date Deposited: | 07 Jul 2020 12:44 |
Last Modified: | 11 Jul 2022 13:39 |
Status: | Published |
Publisher: | Springer Nature |
Identification Number: | 10.1038/s41435-020-0103-y |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:162784 |