O'Connor, DB orcid.org/0000-0003-4117-4093, Gartland, N and O'Connor, RC (2020) Stress, cortisol and suicide risk. In: Clow, A and Smyth, N, (eds.) International Review of Neurobiology. International Review of Neurobiology . Elsevier ISBN 9780128211168
Abstract
Suicide is a global health issue accounting for at least 800,000 deaths per annum. Numerous models have been proposed that differ in their emphasis on the role of psychological, social, psychiatric and neurobiological factors in explaining suicide risk. Central to many models is a stress-diathesis component which states that suicidal behavior is the result of an interaction between acutely stressful events and a susceptibility to suicidal behavior (a diathesis). This article presents an overview of studies that demonstrate that stress and dysregulated hypothalamic-pituitary-adrenal (HPA) axis activity, as measured by cortisol levels, are important additional risk factors for suicide. Evidence for other putative stress-related suicide risk factors including childhood trauma, impaired executive function, impulsivity and disrupted sleep are considered together with the impact of family history of suicide, perinatal and epigenetic influences on suicide risk.
Metadata
Item Type: | Book Section |
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Authors/Creators: |
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Editors: |
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Keywords: | Allostatic load; Childhood trauma; Cortisol awakening response; Cortisol reactivity; Early life adversity; Executive function; Hypothalamic-pituitary-adrenal (HPA) axis; Impulsivity; Sleep; Stress; Suicide |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Psychology (Leeds) |
Funding Information: | Funder Grant number US Army Research Office STEPPS |
Depositing User: | Symplectic Publications |
Date Deposited: | 17 Dec 2019 11:29 |
Last Modified: | 21 Jan 2022 14:04 |
Status: | Published |
Publisher: | Elsevier |
Series Name: | International Review of Neurobiology |
Identification Number: | 10.1016/bs.irn.2019.11.006 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:154701 |