Using 2H Labelling to Improve the NMR detectability of a Series of Pyridines by SABRE

Abstract

By introducing a range of 2H labels into pyridine and the para-substituted agents methyl isonicotinate and isonicotinamide we significantly improve their NMR detectability in conjunction with the Signal Amplification by Reversible Exchange (SABRE) process. We describe how the rates of T1 relaxation for the remaining 1H nuclei are increased and show how this leads to a concomitant increase in the level of 1H and 13C hyperpolarization that can ultimately be detected.

Metadata

Authors/Creators:

Norcott, Philip https://orcid.org/0000-0003-4082-2079
Burns, Michael J. https://orcid.org/0000-0002-5569-1270
Rayner, Peter J. https://orcid.org/0000-0002-6577-4117
Mewis, Ryan E. (rem505@york.ac.uk)
Duckett, Simon B. https://orcid.org/0000-0002-9788-6615

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Dates: