Hurst, Timothy E. orcid.org/0000-0003-0524-2909 and Taylor, Richard J.K. orcid.org/0000-0002-5880-2490 (2017) A Cu-Catalysed Radical Cross-Dehydrogenative Coupling Approach to Acridanes and Related Heterocycles. European Journal of Organic Chemistry. pp. 203-207. ISSN 1099-0690
Abstract
The synthesis of acridanes and related compounds through a Cu-catalysed radical cross-dehydrogenative coupling of simple 2-[2-(arylamino)aryl]malonates is reported. This method can be further streamlined to a one-pot protocol involving the in situ fomation of the 2-[2-(arylamino)aryl]malonate by α-arylation of diethyl malonate with 2-bromodiarylamines under Pd catalysis, followed by Cu-catalysed cyclisation.
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Copyright, Publisher and Additional Information: | © 2017 Wiley-VCH Verlag GmbH & Co. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details | ||||
Keywords: | Acridanes, Copper, Cross-coupling, Dehydrogenation, Homogeneous catalysis, Nitrogen heterocycles, One-pot reaction | ||||
Dates: |
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Institution: | The University of York | ||||
Academic Units: | The University of York The University of York > Faculty of Sciences (York) > Chemistry (York) |
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Depositing User: | Pure (York) | ||||
Date Deposited: | 30 Jan 2017 09:53 | ||||
Last Modified: | 07 Dec 2022 11:06 | ||||
Published Version: | https://doi.org/10.1002/ejoc.201601336 | ||||
Status: | Published | ||||
Refereed: | Yes | ||||
Identification Number: | https://doi.org/10.1002/ejoc.201601336 | ||||
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