Items where authors include "Helleday, T."
Up a levelArticle
Rahman, M.M. orcid.org/0000-0002-2996-8109, Wells, G., Rantala, J.K. et al. (3 more authors) (2024) In-vitro assays for immuno-oncology drug efficacy assessment and screening for personalized cancer therapy: scopes and challenges. Expert Review of Clinical Immunology. ISSN 1744-666X
Marttila, P. orcid.org/0000-0002-0115-8067, Bonagas, N., Chalkiadaki, C. et al. (12 more authors) (2024) The one‐carbon metabolic enzyme MTHFD2 promotes resection and homologous recombination after ionizing radiation. Molecular Oncology. ISSN 1574-7891
Fabbrizi, M.R. orcid.org/0000-0002-5156-1575, Nickson, C.M., Hughes, J.R. orcid.org/0000-0002-6420-2504 et al. (7 more authors) (2024) Targeting OGG1 and PARG radiosensitises head and neck cancer cells to high-LET protons through complex DNA damage persistence. Cell Death & Disease, 15 (2). 150. ISSN 2041-4889
Zhang, S.M., Paulin, C.B.J., Shu, H. et al. (24 more authors) (2024) Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel. iScience, 27 (2). 108907. ISSN 2589-0042
Ramos, L. orcid.org/0000-0002-3808-6853, Henriksson, M. orcid.org/0000-0002-2230-4887, Helleday, T. orcid.org/0000-0002-7384-092X et al. (1 more author) (2023) Targeting MTHFD2 to exploit cancer-specific metabolism and the DNA damage response. Cancer Research. ISSN 0008-5472
Gagg, H. orcid.org/0000-0003-2763-0304, Williams, S.T., Conroy, S. et al. (9 more authors) (2023) Ex-vivo drug screening of surgically resected glioma stem cells to replace murine avatars and provide personalise cancer therapy for glioblastoma patients. F1000Research, 12. 954. ISSN 2046-1402
Odell, L.R. orcid.org/0000-0001-7658-5103, Skillinghaug, B. orcid.org/0000-0002-8014-5757, Matt, C. et al. (7 more authors) (2023) Synthesis of substituted indazole acetic acids by N−N bond forming reactions. European Journal of Organic Chemistry, 26 (29). e202300291. ISSN 1434-193X
Largeot, A., Klapp, V. orcid.org/0000-0001-5507-1963, Viry, E. et al. (30 more authors) (2023) Inhibition of MYC translation through targeting of the newly identified PHB-eIF4F complex as therapeutic strategy in CLL. Blood Journal, 141 (26). pp. 3166-3183. ISSN 0006-4971
Walter, M. orcid.org/0000-0003-3241-522X, Mayr, F. orcid.org/0000-0002-0892-7076, Hanna, B.M.F. orcid.org/0000-0001-7027-6553 et al. (4 more authors) (2023) NUDT22 promotes cancer growth through pyrimidine salvage. Oncogene, 42. pp. 1282-1293. ISSN 0950-9232
Green, A.C. orcid.org/0000-0002-0175-1485, Marttila, P. orcid.org/0000-0002-0115-8067, Kiweler, N. orcid.org/0000-0001-7493-703X et al. (31 more authors) (2023) Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells. Nature Metabolism, 5 (4). pp. 642-659. ISSN 2522-5812
Erlandsson, A. orcid.org/0000-0002-3813-9548, Lundholm, M., Watz, J. et al. (7 more authors) (2023) Infiltrating immune cells in prostate cancer tissue after androgen deprivation and radiotherapy. International Journal of Immunopathology and Pharmacology, 37. ISSN 0394-6320
Pateras, I.S., Williams, C., Gianniou, D.D. et al. (20 more authors) (2023) Short term starvation potentiates the efficacy of chemotherapy in triple negative breast cancer via metabolic reprogramming. Journal of Translational Medicine, 21 (1). 169. ISSN 1479-5876
Tanner, L. orcid.org/0000-0003-0626-9820, Single, A.B., Bhongir, R.K.V. orcid.org/0000-0001-6648-1781 et al. (16 more authors) (2023) Small-molecule-mediated OGG1 inhibition attenuates pulmonary inflammation and lung fibrosis in a murine lung fibrosis model. Nature Communications, 14. 643. ISSN 2041-1723
Helleday, T. and Rudd, S.G. (2022) Targeting the DNA damage response and repair in cancer through nucleotide metabolism. Molecular Oncology, 16 (21). pp. 3792-3810. ISSN 1574-7891
Tanner, L., Bergwik, J., Bhongir, R.K.V. et al. (8 more authors) (2022) Pharmacological OGG1 inhibition decreases murine allergic airway inflammation. Frontiers in Pharmacology, 13. 999180. ISSN 1663-9812
Scaletti, E., Gustafsson Westergren, R., Andersson, Y. et al. (6 more authors) (2022) The first structure of human MTHFD2L and its implications for the development of isoform‐selective inhibitors. ChemMedChem, 17 (18). e202200274. ISSN 1860-7179
Erickson, A., He, M., Berglund, E. et al. (28 more authors) (2022) Spatially resolved clonal copy number alterations in benign and malignant tissue. Nature, 608 (7922). pp. 360-367. ISSN 0028-0836
Jemth, A.-S., Scaletti, E.R., Homan, E. et al. (3 more authors) (2022) Nudix hydrolase 18 catalyzes the hydrolysis of active triphosphate metabolites of the antivirals remdesivir, ribavirin, and molnupiravir. Journal of Biological Chemistry, 298 (8). 102169. ISSN 0021-9258
Benitéz‐Buelga, C., Helleday, T. and Michel, M. (2022) Synthetic switches of OGG1 control initiation of base excision repair and offer new treatment strategies. Clinical and Translational Medicine, 12 (8). e1035. ISSN 2001-1326
Huang, B., Lyu, Z., Qian, Q. et al. (20 more authors) (2022) NUDT1 promotes the accumulation and longevity of CD103+ TRM cells in primary biliary cholangitis. Journal of Hepatology, 77 (5). pp. 1311-1324. ISSN 0168-8278
Baquero, J.M., Marchena-Perea, E., Mirabet, R. et al. (7 more authors) (2022) OGG1 inhibition triggers synthetic lethality and enhances the effect of PARP inhibitor olaparib in BRCA1-deficient TNBC cells. Frontiers in Oncology, 12. 888810. ISSN 2234-943X
Chen, Y., Hua, X., Huang, B. et al. (20 more authors) (2022) MutT homolog 1 inhibitor karonudib attenuates autoimmune hepatitis by inhibiting DNA repair in activated T cells. Hepatology Communications, 6 (5). pp. 1016-1031. ISSN 2471-254X
Das, I., Tuominen, R., Helleday, T. orcid.org/0000-0002-7384-092X et al. (3 more authors) (2022) Coexpression of MTH1 and PMS2 is associated with advanced disease and disease progression after therapy in melanoma. Journal of Investigative Dermatology, 142 (3 Part A). 736-740.e6. ISSN 0022-202X
Williams, S.T., Wells, G. orcid.org/0000-0002-1337-9836, Conroy, S. et al. (9 more authors) (2022) Precision oncology using ex vivo technology: a step towards individualised cancer care? Expert Reviews in Molecular Medicine, 24. e39. ISSN 1462-3994
Sanjiv, K., Calderón-Montaño, J.M., Pham, T.M. et al. (29 more authors) (2021) MTH1 inhibitor TH1579 induces oxidative DNA damage and mitotic arrest in acute myeloid leukemia. Cancer Research, 81 (22). pp. 5733-5744. ISSN 0008-5472
van den Boogaard, M.L., Oka, R., Hakkert, A. et al. (15 more authors) (2021) Defects in 8-oxo-guanine repair pathway cause high frequency of C > A substitutions in neuroblastoma. Proceedings of the National Academy of Sciences, 118 (36). e2007898118. ISSN 0027-8424
Eding, C.B., Köhler, I., Verma, D. et al. (8 more authors) (2021) MTH1 inhibitors for the treatment of psoriasis. Journal of Investigative Dermatology, 141 (8). 2037-2048.e4. ISSN 0022-202X
Zhao, Z., Gad, H. orcid.org/0000-0001-6530-1443, Benitez-Buelga, C. et al. (8 more authors) (2021) NEIL3 prevents senescence in hepatocellular carcinoma by repairing oxidative lesions at telomeres during mitosis. Cancer Research, 81 (15). pp. 4079-4093. ISSN 0008-5472
Hanna, B.M.F., Michel, M., Helleday, T. orcid.org/0000-0002-7384-092X et al. (1 more author) (2021) NEIL1 and NEIL2 are recruited as potential backup for OGG1 upon OGG1 depletion or inhibition by TH5487. International Journal of Molecular Sciences, 22 (9). 4542. ISSN 1661-6596
Rehling, D., Zhang, S.M., Jemth, A.-S. et al. (15 more authors) (2021) Crystal structures of NUDT15 variants enabled by a potent inhibitor reveal the structural basis for thiopurine sensitivity. Journal of Biological Chemistry, 296. 100568. ISSN 0021-9258
Oksvold, M.P., Berglund, U.W., Gad, H. orcid.org/0000-0001-6530-1443 et al. (11 more authors) (2021) Karonudib has potent anti-tumor effects in preclinical models of B-cell lymphoma. Scientific Reports, 11 (1). 6317.
Baquero, J.M., Benítez-Buelga, C., Rajagopal, V. et al. (13 more authors) (2021) Small molecule inhibitor of OGG1 blocks oxidative DNA damage repair at telomeres and potentiates methotrexate anticancer effects. Scientific Reports, 11 (1). 3490.
Visnes, T., Benítez-Buelga, C., Cázares-Körner, A. et al. (43 more authors) (2020) Targeting OGG1 arrests cancer cell proliferation by inducing replication stress. Nucleic Acids Research, 48 (21). pp. 12234-12251. ISSN 0305-1048
Zhang, S.M., Desroses, M., Hagenkort, A. et al. (34 more authors) (2020) Development of a chemical probe against NUDT15. Nature Chemical Biology, 16 (10). pp. 1120-1128. ISSN 1552-4450
Mäkelä, R., Arjonen, A., Suryo Rahmanto, A. et al. (7 more authors) (2020) Ex vivo assessment of targeted therapies in a rare metastatic epithelial–myoepithelial carcinoma. Neoplasia, 22 (9). pp. 390-398. ISSN 1476-5586
Rudd, S.G., Gad, H. orcid.org/0000-0001-6530-1443, Sanjiv, K. et al. (7 more authors) (2020) MTH1 inhibitor TH588 disturbs mitotic progression and induces mitosis-dependent accumulation of genomic 8-oxodG. Cancer Research, 80 (17). pp. 3530-3541. ISSN 0008-5472
Das, I., Gad, H., Bräutigam, L. et al. (9 more authors) (2020) AXL and CAV-1 play a role for MTH1 inhibitor TH1579 sensitivity in cutaneous malignant melanoma. Cell Death & Differentiation, 27. pp. 2081-2098. ISSN 1350-9047
Montanuy, H., Martínez-Barriocanal, A., Casado, J.A. et al. (14 more authors) (2020) Gefitinib and afatinib show potential efficacy for Fanconi anemia-related head and neck cancer. Clinical Cancer Research, 26 (12). pp. 3044-3057. ISSN 1078-0432
Michel, M., Homan, E.J., Wiita, E. et al. (6 more authors) (2020) In silico druggability assessment of the NUDIX hydrolase protein family as a workflow for target prioritization. Frontiers in Chemistry, 8. 443.
Cortiula, F., Pettke, A., Bartoletti, M. et al. (2 more authors) (2020) Managing COVID-19 in the oncology clinic and avoiding the distraction effect. Annals of Oncology, 31 (5). pp. 553-555. ISSN 0923-7534
Scaletti, E.R., Vallin, K.S., Bräutigam, L. et al. (5 more authors) (2020) MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool. Journal of Biological Chemistry, 295 (15). pp. 4761-4772. ISSN 0021-9258
Herr, P. orcid.org/0000-0003-2945-966X, Boström, J., Rullman, E. et al. (6 more authors) (2020) Cell cycle profiling reveals protein oscillation, phosphorylation, and localization dynamics. Molecular & Cellular Proteomics, 19 (4). pp. 608-623. ISSN 1535-9476
Rudd, S.G., Tsesmetzis, N., Sanjiv, K. et al. (32 more authors) (2020) Ribonucleotide reductase inhibitors suppress SAMHD1 ara‐CTPase activity enhancing cytarabine efficacy. EMBO Molecular Medicine, 12 (3). e10419. ISSN 1757-4676
Moukengue, B., Brown, H.K., Charrier, C. et al. (11 more authors) (2020) TH1579, MTH1 inhibitor, delays tumour growth and inhibits metastases development in osteosarcoma model. EBioMedicine, 53. 102704. ISSN 2352-3964
Espinoza, J.A., Zisi, A., Kanellis, D.C. et al. (7 more authors) (2020) The antimalarial drug amodiaquine stabilizes p53 through ribosome biogenesis stress, independently of its autophagy-inhibitory activity. Cell Death & Differentiation, 27 (2). pp. 773-789. ISSN 1350-9047
Rudd, S.G. orcid.org/0000-0002-4368-3855, Gad, H., Amaral, N. et al. (6 more authors) (2019) MTH1 inhibitor TH588 induces mitosis-dependent accumulation of genomic 8-oxodG and disturbs mitotic progression. bioRxiv. (Submitted)
Hua, X., Sanjiv, K., Gad, H. et al. (11 more authors) (2019) Karonudib is a promising anticancer therapy in hepatocellular carcinoma. Therapeutic Advances in Medical Oncology, 11. ISSN 1758-8359
Tepper, S., Mortusewicz, O., Członka, E. et al. (10 more authors) (2019) Restriction of AID activity and somatic hypermutation by PARP-1. Nucleic Acids Research, 47 (14). pp. 7418-7429. ISSN 0305-1048
Michel, M., Visnes, T., Homan, E.J. et al. (12 more authors) (2019) Computational and experimental druggability assessment of human DNA glycosylases. ACS Omega, 4 (7). pp. 11642-11656. ISSN 2470-1343
Yap, T.A., Plummer, R., Azad, N.S. et al. (1 more author) (2019) The DNA damaging revolution : PARP inhibitors and beyond. American Society of Clinical Oncology Educational Book (39). pp. 185-195. ISSN 1548-8748
Jemth, A.-S. orcid.org/0000-0002-7550-1833, Scaletti, E., Carter, M. et al. (2 more authors) (2019) Crystal structure and substrate specificity of the 8-oxo-dGTP hydrolase NUDT1 from Arabidopsis thaliana. Biochemistry, 58 (7). pp. 887-899. ISSN 0006-2960
Lallo, A., Gulati, S., Schenk, M.W. et al. (12 more authors) (2019) Ex vivo culture of cells derived from circulating tumour cell xenograft to support small cell lung cancer research and experimental therapeutics. British Journal of Pharmacology, 176 (3). pp. 436-450. ISSN 0007-1188
Jemth, A-S., Gustafsson, R., Bräutigam, L. et al. (9 more authors) (2018) MutT homologue 1 (MTH1) catalyzes the hydrolysis of mutagenic O6-methyl-dGTP. Nucleic Acids Research, 46 (20). pp. 10888-10904. ISSN 0305-1048
Visnes, T., Cázares-Körner, A., Hao, W. et al. (37 more authors) (2018) Small-molecule inhibitor of OGG1 suppresses pro-inflammatory gene expression and inflammation. Science, 362 (6416). pp. 834-839. ISSN 0036-8075
Visnes, T., Grube, M., Hanna, B.M.F. et al. (3 more authors) (2018) Targeting BER enzymes in cancer therapy. DNA Repair, 71. pp. 118-126. ISSN 1568-7864
Desroses, M., Busker, S., Astorga-Wells, J. et al. (6 more authors) (2018) STAT3 differential scanning fluorimetry and differential scanning light scattering assays: Addressing a missing link in the characterization of STAT3 inhibitor interactions. Journal of Pharmaceutical and Biomedical Analysis , 160. pp. 80-88. ISSN 0731-7085
Burgos-Morón, E., Calderón-Montaño, J.M., Pastor, N. et al. (8 more authors) (2018) The Cockayne syndrome protein B is involved in the repair of 5-AZA-2'-deoxycytidine-induced DNA lesions. Oncotarget, 9 (80). pp. 35069-35084.
Gustafsson, N.M.S., Farnegardh, K., Bonagas, N. et al. (18 more authors) (2018) Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination. Nature Communications, 9. 3872. ISSN 2041-1723
Einarsdottir, B.O., Karlsson, J., Söderberg, E.M.V. et al. (16 more authors) (2018) A patient-derived xenograft pre-clinical trial reveals treatment responses and a resistance mechanism to karonudib in metastatic melanoma. Cell Death and Disease, 9 (8). 810. ISSN 2041-4889
Berglund, E., Maaskola, J., Schultz, N. et al. (15 more authors) (2018) Spatial maps of prostate cancer transcriptomes reveal an unexplored landscape of heterogeneity. Nature Communications, 9 (1). 2419. ISSN 2041-1723
Carter, M., Jemth, A.-S., Carreras-Puigvert, J. et al. (6 more authors) (2018) Human NUDT22 is a UDP-glucose/galactose hydrolase exhibiting a unique structural fold. Structure, 26 (2). 295-303.e6. ISSN 0969-2126
Page, B.D.G., Valerie, N.C.K., Wright, R.H.G. et al. (22 more authors) (2018) Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells. Nature Communications, 9 (1). 250. ISSN 2041-1723
Thålin, C., Lundström, S., Seignez, C. et al. (7 more authors) (2018) Citrullinated histone H3 as a novel prognostic blood marker in patients with advanced cancer. PLoS ONE, 13 (1). e0191231. ISSN 1932-6203
Carreras-Puigvert, J., Zitnik, M., Jemth, A.-S. et al. (21 more authors) (2017) A comprehensive structural, biochemical and biological profiling of the human NUDIX hydrolase family. Nature Communications, 8 (1). 1541. ISSN 2041-1723
Pudelko, L., Rouhi, P., Sanjiv, K. et al. (10 more authors) (2017) Glioblastoma and glioblastoma stem cells are dependent on functional MTH1. Oncotarget, 8 (49). pp. 94671-84684.
Asim, M., Tarish, F., Zecchini, H.I. et al. (27 more authors) (2017) Synthetic lethality between androgen receptor signalling and the PARP pathway in prostate cancer. Nature Communications, 8 (1). 374. ISSN 2041-1723
Tsuber, V., Kadamov, Y., Brautigam, L. et al. (2 more authors) (2017) Mutations in cancer cause gain of cysteine, histidine, and tryptophan at the expense of a net loss of arginine on the proteome level. Biomolecules, 7 (3). 49. ISSN 2218-273X
Kolosenko, I., Yu, Y., Busker, S. et al. (8 more authors) (2017) Identification of novel small molecules that inhibit STAT3-dependent transcription and function. PLoS ONE, 12 (6). e0178844. ISSN 1932-6203
Hagenkort, A., Paulin, C.B.J., Desroses, M. et al. (12 more authors) (2017) dUTPase inhibition augments replication defects of 5-Fluorouracil. Oncotarget, 8 (14). pp. 23713-23726.
Sokolova, M., Turunen, M., Mortusewicz, O. et al. (7 more authors) (2017) Genome-wide screen of cell-cycle regulators in normal and tumor cells identifies a differential response to nucleosome depletion. Cell Cycle, 16 (2). pp. 189-199. ISSN 1538-4101
Ogris, C., Guala, D., Helleday, T. orcid.org/0000-0002-7384-092X et al. (1 more author) (2017) A novel method for crosstalk analysis of biological networks: improving accuracy of pathway annotation. Nucleic Acids Research, 45 (2). e8. ISSN 0305-1048
Eshtad, S., Mavajian, Z., Rudd, S.G. et al. (4 more authors) (2016) hMYH and hMTH1 cooperate for survival in mismatch repair defective T-cell acute lymphoblastic leukemia. Oncogenesis, 5 (12). e275. ISSN 2157-9024
Tanikawa, M., Sanjiv, K., Helleday, T. orcid.org/0000-0002-7384-092X et al. (2 more authors) (2016) The spliceosome U2 snRNP factors promote genome stability through distinct mechanisms; transcription of repair factors and R-loop processing. Oncogenesis, 5 (12). e280. ISSN 2157-9024
Valerie, N.C.K., Hagenkort, A., Page, B.D.G. et al. (10 more authors) (2016) NUDT15 hydrolyzes 6-thio-deoxyGTP to mediate the anticancer efficacy of 6-thioguanine. Cancer Research, 76 (18). pp. 5501-5511. ISSN 0008-5472
Ogris, C., Helleday, T. orcid.org/0000-0002-7384-092X and Sonnhammer, E.L.L. (2016) PathwAX: a web server for network crosstalk based pathway annotation. Nucleic Acids Research, 44 (W1). W105-W109. ISSN 0305-1048
Rassoolzadeh, H., Böhm, S., Hedström, E. et al. (4 more authors) (2016) Overexpression of the scaffold WD40 protein WRAP53β enhances the repair of and cell survival from DNA double-strand breaks. Cell Death & Disease, 7 (6). e2267.
Herr, P. orcid.org/0000-0003-2945-966X, Lundin, C., Evers, B. et al. (8 more authors) (2015) A genome-wide IR-induced RAD51 foci RNAi screen identifies CDC73 involved in chromatin remodeling for DNA repair. Cell Discovery, 1. 15034.
Xing, M., Wang, X., Palmai-Pallag, T. et al. (4 more authors) (2015) Acute MUS81 depletion leads to replication fork slowing and a constitutive DNA damage response. Oncotarget, 6 (35). pp. 37638-37646.
Carter, M., Jemth, A.-S., Hagenkort, A. et al. (10 more authors) (2015) Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2. Nature Communications, 6. 7871.
Luis Orta, M., Höglund, A., Calderón-Montaño, J.M. et al. (7 more authors) (2014) The PARP inhibitor Olaparib disrupts base excision repair of 5-aza-2'-deoxycytidine lesions. Nucleic Acids Research, 42 (14). pp. 9108-9120. ISSN 0305-1048
Bolderson, E., Petermann, E., Croft, L. et al. (6 more authors) (2014) Human single-stranded DNA binding protein 1 (hSSB1/NABP2) is required for the stability and repair of stalled replication forks. Nucleic Acids Research, 42 (10). pp. 6326-6336. ISSN 0305-1048
Gao, C., Bourke, E., Scobie, M. et al. (6 more authors) (2014) Rational design and validation of a Tip60 histone acetyltransferase inhibitor. Scientific Reports, 4. 5372.
Luis Orta, M., Manuel Calderon-Montano, J., Dominguez, I. et al. (6 more authors) (2013) 5-Aza-2'-deoxycytidine causes replication lesions that require Fanconi anemia-dependent homologous recombination for repair. Nucleic Acids Research, 41 (11). pp. 5827-5836. ISSN 0305-1048
Burrell, R.A., McClelland, S.E., Endesfelder, D. et al. (18 more authors) (2013) Replication stress links structural and numerical cancer chromosomal instability. Nature, 494 (7438). pp. 492-496. ISSN 0028-0836
Ström, C.E. and Helleday, T. orcid.org/0000-0002-7384-092X (2012) Strategies for the use of poly(adenosine diphosphate ribose) polymerase (PARP) inhibitors in cancer therapy. Biomolecules, 2 (4). pp. 635-649.
Elvers, I., Hagenkort, A., Johansson, F. et al. (6 more authors) (2012) CHK1 activity is required for continuous replication fork elongation but not stabilization of post-replicative gaps after UV irradiation. Nucleic Acids Research, 40 (17). pp. 8440-8448. ISSN 0305-1048
Groth, P., Luis Orta, M., Elvers, I. et al. (3 more authors) (2012) Homologous recombination repairs secondary replication induced DNA double-strand breaks after ionizing radiation. Nucleic Acids Research, 40 (14). pp. 6585-6594. ISSN 0305-1048
Elvers, I., Johansson, F., Groth, P. et al. (2 more authors) (2011) UV stalled replication forks restart by re-priming in human fibroblasts. Nucleic Acids Research, 39 (16). pp. 7049-7057. ISSN 0305-1048
Kondo, N., Takahashi, A., Mori, E. et al. (10 more authors) (2011) FANCD1/BRCA2 plays predominant role in the repair of DNA damage induced by ACNU or TMZ. PLoS ONE, 6 (5). e19659.
Stoimenov, I., Schultz, N., Gottipati, P. et al. (1 more author) (2011) Transcription inhibition by DRB potentiates recombinational repair of UV lesions in mammalian cells. PLoS ONE, 6 (5). e19492.
Ström, C.E., Johansson, F., Uhlen, M. et al. (3 more authors) (2011) Poly (ADP-ribose) polymerase (PARP) is not involved in base excision repair but PARP inhibition traps a single-strand intermediate. Nucleic Acids Research, 39 (8). pp. 3166-3175. ISSN 0305-1048
Hawtin, R.E., Stockett, D.E., Wong, O.K. et al. (3 more authors) (2010) Homologous recombination repair is essential for repair of vosaroxin-induced DNA double-strand breaks. Oncotarget, 1 (7). pp. 606-619.
Higgins, G.S., Harris, A.L., Prevo, R. et al. (3 more authors) (2010) Overexpression of POLQ confers a poor prognosis in early breast cancer patients. Oncotarget, 1 (3). pp. 175-184.
Beck, H., Nahse, V., Larsen, M.S.Y. et al. (7 more authors) (2010) Regulators of cyclin-dependent kinases are crucial for maintaining genome integrity in S phase. Journal of Cell Biology, 188 (5). pp. 629-638. ISSN 0021-9525
Al-Minawi, A. Z., Lee, Y. F., Hakansson, D. et al. (9 more authors) (2009) The ERCC1/XPF endonuclease is required for completion of homologous recombination at DNA replication forks stalled by inter-strand cross-links. Nucleic Acids Research, 37 (19). pp. 6400-6413. ISSN 0305-1048
Ying, S.M., Myers, K., Bottomley, S. et al. (2 more authors) (2009) BRCA2-dependent homologous recombination is required for repair of Arsenite-induced replication lesions in mammalian cells. Nucleic Acids Research, 37 (15). pp. 5105-5113. ISSN 0305-1048
Savolainen, L. and Helleday, T. orcid.org/0000-0002-7384-092X (2009) Transcription-associated recombination is independent of XRCC2 and mechanistically separate from homology-directed DNA double-strand break repair. Nucleic Acids Research, 37 (2). pp. 405-412. ISSN 0305-1048
Al-Minawi, A.Z., Saleh-Gohari, N. and Helleday, T. orcid.org/0000-0002-7384-092X (2008) The ERCC1/XPF endonuclease is required for efficient single-strand annealing and gene conversion in mammalian cells. Nucleic Acids Research, 36 (1). pp. 1-9. ISSN 0305-1048
Jorgensen, S., Elvers, I., Trelle, M.B. et al. (6 more authors) (2007) The histone methyltransferase SET8 is required for S-phase progression. Journal of Cell Biology, 179 (7). pp. 1337-1345. ISSN 0021-9525
Bryant, H.E. and Helleday, T. (2006) Inhibition of poly (ADP-ribose) polymerase activates ATM which is required for subsequent homologous recombination repair. Nucleic Acids Research, 34 (6). pp. 1685-1691. ISSN 0305-1048
Lundin, C., North, M., Erixon, K. et al. (4 more authors) (2005) Methyl methanesulfonate (MMS) produces heat-labile DNA damage but no detectable in vivo DNA double-strand breaks. NUCLEIC ACIDS RESEARCH, 33 (12). pp. 3799-3811. ISSN 0305-1048
Proceedings Paper
Gagg, H., Williams, S., Allen, R. orcid.org/0000-0003-2448-7987 et al. (7 more authors) (2022) F-1286: Ex vivo-led drug discovery in glioblastoma. In: Brain Tumor Research and Treatment. 6th Quadrennial Meeting of the World Federation of Neuro-oncology Societies (WFNOS 2022), 24-27 Mar 2022, Seoul, Korea. Korean Brain Tumor Society; Korea Society for Neuro-Oncology , s240.
Walter, M. orcid.org/0000-0003-3241-522X, Homan, E., Koolmeister, T. et al. (3 more authors) (2021) Development of small molecule NUDT22 inhibitors for uses in cancer. In: Medical Sciences Forum. IECC 2021: 1st International Electronic Conference on Cancers, 01-14 Feb 2021, Online. MDPI .
Sanjiv, K., Gad, H., Rudd, S. et al. (15 more authors) (2016) Polymerase kappa determines the sensitivity of MTH1 inhibitors to cisplatin-resistant cell. In: Cancer Research. AACR 107th Annual Meeting 2016, 16-20 Apr 2016, New Orleans, LA, USA. American Association for Cancer Research .