OGG1 inhibition triggers synthetic lethality and enhances the effect of PARP inhibitor olaparib in BRCA1-deficient TNBC cells

Baquero, J.M., Marchena-Perea, E., Mirabet, R. et al. (7 more authors) (2022) OGG1 inhibition triggers synthetic lethality and enhances the effect of PARP inhibitor olaparib in BRCA1-deficient TNBC cells. Frontiers in Oncology, 12. 888810. ISSN 2234-943X

Abstract

Metadata

Authors/Creators:
  • Baquero, J.M.
  • Marchena-Perea, E.
  • Mirabet, R.
  • Torres-Ruiz, R.
  • Blanco-Aparicio, C.
  • Rodríguez-Perales, S.
  • Helleday, T.
  • Benítez-Buelga, C.
  • Benítez, J.
  • Osorio, A.
Copyright, Publisher and Additional Information: © 2022 Baquero, Marchena-Perea, Mirabet, Torres-Ruiz, Blanco-Aparicio, Rodríguez-Perales, Helleday, Benítez-Buelga, Benítez and Osorio. This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Keywords: BRCA1; OGG1 inhibitor; PARP1 inhibitor; triple negative breast cancer; synthetic lethality
Dates:
  • Accepted: 13 April 2022
  • Published (online): 10 May 2022
  • Published: 10 May 2022
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > Department of Human Metabolism (Sheffield)
The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > Department of Oncology (Sheffield)
Depositing User: Symplectic Sheffield
Date Deposited: 31 May 2022 14:41
Last Modified: 31 May 2022 14:41
Status: Published
Publisher: Frontiers Media
Refereed: Yes
Identification Number: https://doi.org/10.3389/fonc.2022.888810

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