Ribonucleotide reductase inhibitors suppress SAMHD1 ara‐CTPase activity enhancing cytarabine efficacy

Rudd, S.G., Tsesmetzis, N., Sanjiv, K. et al. (32 more authors) (2020) Ribonucleotide reductase inhibitors suppress SAMHD1 ara‐CTPase activity enhancing cytarabine efficacy. EMBO Molecular Medicine, 12 (3). e10419. ISSN 1757-4676

Abstract

Metadata

Authors/Creators:
  • Rudd, S.G.
  • Tsesmetzis, N.
  • Sanjiv, K.
  • Paulin, C.B.J.
  • Sandhow, L.
  • Kutzner, J.
  • Hed Myrberg, I.
  • Bunten, S.S.
  • Axelsson, H.
  • Zhang, S.M.
  • Rasti, A.
  • Mäkelä, P.
  • Coggins, S.A.
  • Tao, S.
  • Suman, S.
  • Branca, R.M.
  • Mermelekas, G.
  • Wiita, E.
  • Lee, S.
  • Walfridsson, J.
  • Schinazi, R.F.
  • Kim, B.
  • Lehtiö, J.
  • Rassidakis, G.Z.
  • Pokrovskaja Tamm, K.
  • Warpman‐Berglund, U.
  • Heyman, M.
  • Grandér, D.
  • Lehmann, S.
  • Lundbäck, T.
  • Qian, H.
  • Henter, J.
  • Schaller, T.
  • Helleday, T. ORCID logo https://orcid.org/0000-0002-7384-092X
  • Herold, N.
Copyright, Publisher and Additional Information: © 2020 The Authors. This is an open access article under the terms of the Creative Commons Attribution 4.0 License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited (http://creativecommons.org/licenses/by/4.0/).
Keywords: acute myeloid leukaemia; chemotherapy resistance; drug synergy; precision medicine; SAMHD1
Dates:
  • Accepted: 17 December 2019
  • Published (online): 17 January 2020
  • Published: 6 March 2020
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield)
Depositing User: Symplectic Sheffield
Date Deposited: 09 Mar 2020 12:50
Last Modified: 09 Mar 2020 12:50
Status: Published
Publisher: EMBO Press
Refereed: Yes
Identification Number: https://doi.org/10.15252/emmm.201910419
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