Items where authors include "Wiita, E."

Article

Luttens, A. orcid.org/0000-0003-2915-7901, Vo, D.D., Scaletti, E.R. et al. (22 more authors) (2025) Virtual fragment screening for DNA repair inhibitors in vast chemical space. Nature Communications, 16. 1741. ISSN 2041-1723

Marttila, P. orcid.org/0000-0002-0115-8067, Bonagas, N., Chalkiadaki, C. et al. (12 more authors) (2024) The one‐carbon metabolic enzyme MTHFD2 promotes resection and homologous recombination after ionizing radiation. Molecular Oncology, 18 (9). pp. 2179-2195. ISSN 1574-7891

Zhang, S.M., Paulin, C.B.J., Shu, H. et al. (24 more authors) (2024) Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel. iScience, 27 (2). 108907. ISSN 2589-0042

Green, A.C. orcid.org/0000-0002-0175-1485, Marttila, P. orcid.org/0000-0002-0115-8067, Kiweler, N. orcid.org/0000-0001-7493-703X et al. (31 more authors) (2023) Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells. Nature Metabolism, 5 (4). pp. 642-659. ISSN 2522-5812

Scaletti, E., Gustafsson Westergren, R., Andersson, Y. et al. (6 more authors) (2022) The first structure of human MTHFD2L and its implications for the development of isoform‐selective inhibitors. ChemMedChem, 17 (18). e202200274. ISSN 1860-7179

Sanjiv, K., Calderón-Montaño, J.M., Pham, T.M. et al. (29 more authors) (2021) MTH1 inhibitor TH1579 induces oxidative DNA damage and mitotic arrest in acute myeloid leukemia. Cancer Research, 81 (22). pp. 5733-5744. ISSN 0008-5472

Visnes, T., Benítez-Buelga, C., Cázares-Körner, A. et al. (43 more authors) (2020) Targeting OGG1 arrests cancer cell proliferation by inducing replication stress. Nucleic Acids Research, 48 (21). pp. 12234-12251. ISSN 0305-1048

Zhang, S.M., Desroses, M., Hagenkort, A. et al. (34 more authors) (2020) Development of a chemical probe against NUDT15. Nature Chemical Biology, 16 (10). pp. 1120-1128. ISSN 1552-4450

Michel, M., Homan, E.J., Wiita, E. et al. (6 more authors) (2020) In silico druggability assessment of the NUDIX hydrolase protein family as a workflow for target prioritization. Frontiers in Chemistry, 8. 443.

Rudd, S.G., Tsesmetzis, N., Sanjiv, K. et al. (32 more authors) (2020) Ribonucleotide reductase inhibitors suppress SAMHD1 ara‐CTPase activity enhancing cytarabine efficacy. EMBO Molecular Medicine, 12 (3). e10419. ISSN 1757-4676

Michel, M., Visnes, T., Homan, E.J. et al. (12 more authors) (2019) Computational and experimental druggability assessment of human DNA glycosylases. ACS Omega, 4 (7). pp. 11642-11656. ISSN 2470-1343

Visnes, T., Cázares-Körner, A., Hao, W. et al. (37 more authors) (2018) Small-molecule inhibitor of OGG1 suppresses pro-inflammatory gene expression and inflammation. Science, 362 (6416). pp. 834-839. ISSN 0036-8075

Gustafsson, N.M.S., Farnegardh, K., Bonagas, N. et al. (18 more authors) (2018) Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination. Nature Communications, 9. 3872. ISSN 2041-1723

Hagenkort, A., Paulin, C.B.J., Desroses, M. et al. (12 more authors) (2017) dUTPase inhibition augments replication defects of 5-Fluorouracil. Oncotarget, 8 (14). pp. 23713-23726.