Items where authors include "Totton, N."

Article

Lepage, S., Whelan, B., Flight, L. et al. (2 more authors) (2025) Lessons learned from building the kid’s trial with an online children’s and parents’ research advisory group: a descriptive, qualitative study. Research Involvement and Engagement, 11 (1). 72. ISSN 2056-7529

Deery, C. orcid.org/0000-0001-7526-7736, Bolt, R. orcid.org/0009-0007-1705-8400, Papaioannou, D. orcid.org/0000-0002-6259-0822 et al. (25 more authors) (2025) Melatonin versus midazolam in the premedication of anxious children attending for elective surgery under general anaesthesia: the MAGIC non-inferiority RCT. Health Technology Assessment, 29 (29). ISSN 1366-5278

Bellamy, M. orcid.org/0009-0003-7402-8049, Tung, W.S., Jayasuriya, R. orcid.org/0000-0002-0798-9128 et al. (4 more authors) (2025) Bracing effectiveness in idiopathic early onset scoliosis followed to skeletal maturity: a systematic review and meta-analysis. Spine Deformity, 13 (3). pp. 939-950. ISSN 2212-134X

Girling, C. orcid.org/0000-0003-4216-214X, Davids, I. orcid.org/0000-0003-4900-7695, Totton, N. et al. (3 more authors) (2025) Changing practice in cystic fibrosis: implementing objective medication adherence data at every consultation, a learning health system and quality improvement collaborative. Learning Health Systems, 9 (2). e10453. ISSN 2379-6146

Bentham, R., Jones, T.P. orcid.org/0000-0003-2748-0780, Black, J.R.M. orcid.org/0000-0001-5598-7752 et al. (327 more authors) (2025) ImmuneLENS characterizes systemic immune dysregulation in aging and cancer. Nature Genetics, 57. pp. 694-705. ISSN 1061-4036

Biswas, D. orcid.org/0000-0001-9141-5188, Liu, Y.-H. orcid.org/0009-0001-1508-5276, Herrero, J. orcid.org/0000-0001-7313-717X et al. (267 more authors) (2025) Prospective validation of ORACLE, a clonal expression biomarker associated with survival of patients with lung adenocarcinoma. Nature Cancer, 6. pp. 86-101. ISSN 2662-1347

Black, J.R.M. orcid.org/0000-0001-5598-7752, Bartha, G., Abbott, C.W. et al. (277 more authors) (2025) Ultrasensitive ctDNA detection for preoperative disease stratification in early-stage lung adenocarcinoma. Nature Medicine, 31 (1). pp. 70-76. ISSN 1078-8956

Kettle, J., Bolt, R., Deery, C. et al. (5 more authors) (2024) Acceptability of midazolam and melatonin as premedications for anxious children undergoing general anaesthesia: a qualitative interview study with children, caregivers and health professionals participating in the MAGIC trial. Trials, 25 (1). 813. ISSN 1745-6215

Totton, N. orcid.org/0000-0002-1900-2773, Julious, S., Walters, S. et al. (1 more author) (2024) A review of UK publicly funded non-inferiority trials: is the design more inferior than it should be? Trials, 25 (1). 809. ISSN 1745-6215

Herbert, E. orcid.org/0000-0002-1224-5457, Papaioannou, D., Loban, A. et al. (4 more authors) (2024) Personalised versus standard text message prompts for increasing trial participant response to telephone follow-up: an embedded randomised controlled retention trial. Trials, 25 (1). 108. ISSN 1745-6215

Puttick, C. orcid.org/0009-0006-3022-8737, Jones, T.P. orcid.org/0000-0003-2748-0780, Leung, M.M. orcid.org/0000-0001-9555-1080 et al. (279 more authors) (2024) MHC Hammer reveals genetic and non-genetic HLA disruption in cancer evolution. Nature Genetics, 56. pp. 2121-2131. ISSN 1061-4036

Totton, N. orcid.org/0000-0002-1900-2773, Waddingham, E., Owen, R. et al. (3 more authors) (2024) A proposal for using benefit-risk methods to improve the prominence of adverse event results when reporting trials. Trials, 25. 409. ISSN 1745-6215

Hobor, S., Al Bakir, M. orcid.org/0000-0002-0846-8332, Hiley, C.T. et al. (292 more authors) (2024) Mixed responses to targeted therapy driven by chromosomal instability through p53 dysfunction and genome doubling. Nature Communications, 15. 4871. ISSN 2041-1723

Hynds, R.E. orcid.org/0000-0002-2170-8791, Huebner, A. orcid.org/0000-0001-8009-4999, Pearce, D.R. orcid.org/0000-0001-8443-2924 et al. (274 more authors) (2024) Representation of genomic intratumor heterogeneity in multi-region non-small cell lung cancer patient-derived xenograft models. Nature Communications, 15 (1). 4653. ISSN 2041-1723

Bolt, R. orcid.org/0009-0007-1705-8400, Hyslop, M.C. orcid.org/0009-0005-7078-4933, Herbert, E. orcid.org/0000-0002-1224-5457 et al. (56 more authors) (2024) The MAGIC trial: a pragmatic, multicentre, parallel, noninferiority, randomised trial of melatonin versus midazolam in the premedication of anxious children attending for elective surgery under general anaesthesia. British Journal of Anaesthesia, 132 (1). pp. 76-85. ISSN 0007-0912

Goulão, B. orcid.org/0000-0003-1490-7183, Morris, T.P. orcid.org/0000-0001-5850-3610, Blazeby, J. et al. (7 more authors) (2023) Involving patients and the public In sTatistIcal Analysis pLans (INITIAL): a delphi survey. PLOS ONE, 18 (12). e0292257. ISSN 1932-6203

Totton, N. orcid.org/0000-0002-1900-2773, Lin, J., Julious, S. orcid.org/0000-0002-9917-7636 et al. (2 more authors) (2023) A review of sample sizes for UK pilot and feasibility studies on the ISRCTN registry from 2013 to 2020. Pilot and Feasibility Studies, 9 (1). 188. ISSN 2055-5784

Swaby, L. orcid.org/0000-0001-9443-7681, Perry, D.C. orcid.org/0000-0001-8420-8252, Walker, K. et al. (17 more authors) (2023) Bracing adolescent idiopathic scoliosis (BASIS) study – night-time versus full-time bracing in adolescent idiopathic scoliosis: study protocol for a multicentre, randomized controlled trial. Bone & Joint Open, 4 (11). pp. 873-880.

Totton, N. orcid.org/0000-0002-1900-2773, Julious, S.A. orcid.org/0000-0002-9917-7636, Coates, E. orcid.org/0000-0002-2388-6102 et al. (6 more authors) (2023) Appropriate design and reporting of superiority, equivalence and non-inferiority clinical trials incorporating a benefit–risk assessment: the BRAINS study including expert workshop. Health Technology Assessment, 27 (20). ISSN 1366-5278

Sheldon, E.M. orcid.org/0000-0002-1927-471X, Lillington, G., Simpson, K. et al. (11 more authors) (2023) Development of an inflammatory bowel disease (IBD) Patient‐Reported Experience Measure (PREM): A patient‐led consensus work and ‘think aloud’ study for a quality improvement programme. Health Expectations, 26 (1). pp. 213-225. ISSN 1369-6513

Attard, N., Totton, N. orcid.org/0000-0002-1900-2773, Gillies, K. et al. (1 more author) (2022) How do we know a treatment is good enough? A survey of non-inferiority trials. Trials, 23. 1021. ISSN 1745-6215

Coates, E. orcid.org/0000-0002-2388-6102, Wickramasekera, N. orcid.org/0000-0002-6552-5153, Barr, A. orcid.org/0000-0002-7990-7451 et al. (10 more authors) (2022) Patient preferences and current practice for adults with steroid-resistant ulcerative colitis: POPSTER mixed-methods study. Health Technology Assessment, 26 (41). ISSN 1366-5278

Totton, N., Bradburn, M. orcid.org/0000-0002-3783-9761, Hoo, Z.H. et al. (14 more authors) (2021) Prospectively predicting Pseudomonas aeruginosa infection/s using routine data from the UK cystic fibrosis register. Health Science Reports, 4 (4). e381. ISSN 2398-8835

Hoo, Z.H. orcid.org/0000-0002-7067-3783, Totton, N., Waterhouse, S. et al. (25 more authors) (2021) Real-world adherence among adults with cystic fibrosis is low – a retrospective analysis of the CFHealthHub digital learning health system. Chest, 160 (6). pp. 2061-2065. ISSN 0012-3692

Ali, A., Tabassum, D., Baig, S.S. et al. (8 more authors) (2021) Effect of exercise interventions on health-related quality of life after stroke and transient ischemic attack: a systematic review and meta-analysis. Stroke, 52 (7). pp. 2445-2455. ISSN 0039-2499

Totton, N., Julious, S. orcid.org/0000-0002-9917-7636, Hughes, D. et al. (6 more authors) (2021) Utilising benefit-risk assessments within clinical trials—a protocol for the BRAINS project. Trials, 22. 68. ISSN 1745-6215

Coates, E., Amiel, S., Baird, W. et al. (31 more authors) (2021) Protocol for a cluster randomised controlled trial of the DAFNEplus (Dose Adjustment for Normal Eating) intervention compared with 5x1 DAFNE : a lifelong approach to promote effective self-management in adults with type 1 diabetes. BMJ Open, 11 (1). e040438. ISSN 2044-6055

Walters, S.J. orcid.org/0000-0001-9000-8126, Jacques, R.M. orcid.org/0000-0001-6710-5403, dos Anjos Henriques-Cadby, I.B. et al. (3 more authors) (2019) Sample size estimation for randomised controlled trials with repeated assessment of patient-reported outcomes : what correlation between baseline and follow-up outcomes should we assume? Trials, 20 (1). 566.

Roberts, J.L. orcid.org/0000-0002-3271-1814, Pritchard, A.W., Williams, M. et al. (4 more authors) (2018) Mixed methods process evaluation of an enhanced community-based rehabilitation intervention for elderly patients with hip fracture. BMJ Open, 8 (8). e021486. ISSN 2044-6055

Ngu, W., Walls, M., Bhandari, P. et al. (5 more authors) (2018) The B-ADENOMA study: Bowelscope – Accuracy of detection using endocuff optimisation of mucosal abnormalities: Study protocol for randomised controlled trial. Endoscopy International Open, 06 (07). E872-E877. ISSN 2364-3722

Williams, N.H., Mawdesley, K., Roberts, J.L. et al. (5 more authors) (2018) Hip fracture in the elderly multidisciplinary rehabilitation (FEMuR) feasibility study: testing the use of routinely collected data for future health economic evaluations. Pilot and Feasibility Studies, 4. 76. ISSN 2055-5784

Morrison, V., Spencer, L.H., Totton, N. orcid.org/0000-0002-1900-2773 et al. (11 more authors) (2018) Trial of Optimal Personalised Care After Treatment - Gynaecological Cancer (TOPCAT-G): A randomized feasibility trial. International Journal of Gynecological Cancer, 28 (2). pp. 401-411. ISSN 1048-891X

Williams, N.H., Roberts, J.L., Din, N.U. et al. (16 more authors) (2017) Developing a multidisciplinary rehabilitation package following hip fracture and testing in a randomised feasibility study: Fracture in the Elderly Multidisciplinary Rehabilitation (FEMuR). Health Technology Assessment, 21 (44). pp. 1-528.

Pye, K., Totton, N. orcid.org/0000-0002-1900-2773, Stuart, N. et al. (12 more authors) (2016) Trial of Optimal Personalised Care After Treatment for Gynaecological cancer (TOPCAT-G): a study protocol for a randomised feasibility trial. Pilot and Feasibility Studies, 2 (1). 67.

Williams, N.H., Roberts, J.L., Din, N.U. et al. (14 more authors) (2016) Fracture in the Elderly Multidisciplinary Rehabilitation (FEMuR): a phase II randomised feasibility study of a multidisciplinary rehabilitation package following hip fracture. BMJ Open, 6 (10). e012422. ISSN 2044-6055

Proceedings Paper

Totton, N., Sheldon, E., Ezaydi, N. et al. (4 more authors) (2024) Validation of a newly developed patient-reported experience measure for people with Inflammatory bowel disease. In: Journal of Crohn's and Colitis. 19th Congress of ECCO, 21-24 Feb 2024, Stockholm, Sweden. , I837-I837.

Coates, E., Barr, A., Totton, N. orcid.org/0000-0002-1900-2773 et al. (9 more authors) (2021) P97 Management of steroid resistant ulcerative colitis – a national survey of UK practice. In: Gut. BSG Campus, 21-29 Jan 2021, Virtual. BMJ Publishing Group Ltd , a91-a91.

Totton, N., Julious, S., Hughes, D. et al. (1 more author) (2019) MRC-NIHR methodology guideline development on utilising benefit-risk assessments within clinical trials. In: Trials. 5th International Clinical Trials Methodology Conference (ICTMC 2019), 06-09 Oct 2019, Brighton, UK. BioMed Central , p. 93.