Items where authors include "Richards, MW"

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Number of items: 15.

Article

Sampson, J orcid.org/0000-0002-0147-6014, Richards, MW orcid.org/0000-0003-1108-2825, Choi, J et al. (2 more authors) (2021) Phase‐separated foci of EML4‐ALK facilitate signalling and depend upon an active kinase conformation. EMBO Reports, 22 (12). e53693. ISSN 1469-221X

Poon, E, Liang, T, Jamin, Y et al. (40 more authors) (2020) Orally bioavailable CDK9/2 inhibitor shows mechanism-based therapeutic potential in MYCN-driven neuroblastoma. Journal of Clinical Investigation. ISSN 0021-9738

Matheson, CJ, Coxon, CR, Bayliss, R orcid.org/0000-0003-0604-2773 et al. (13 more authors) (2020) 2-Arylamino-6-ethynylpurines are cysteine-targeting irreversible inhibitors of Nek2 kinase. RSC Medicinal Chemistry, 11 (6). pp. 707-731. ISSN 2632-8682

O'Regan, L, Barone, G, Adib, R et al. (10 more authors) (2020) EML4-ALK V3 oncogenic fusion proteins promote microtubule stabilization and accelerated migration through NEK9 and NEK7. Journal of Cell Science. jcs.241505. jcs.241505-jcs.241505. ISSN 0021-9533

Adib, R, Montgomery, JM, Atherton, J et al. (8 more authors) (2019) Mitotic phosphorylation by NEK6 and NEK7 reduces the microtubule affinity of EML4 to promote chromosome congression. Science signaling, 12 (594). ARTN eaaw2939. ISSN 1945-0877

Mukherjee, M orcid.org/0000-0002-3615-7574, Sabir, S, O'Regan, L et al. (8 more authors) (2018) Mitotic phosphorylation regulates Hsp72 spindle localization by uncoupling ATP binding from substrate release. Science signaling, 11 (543). eaao2464. ISSN 1945-0877

Burgess, SG orcid.org/0000-0003-0361-0691, Mukherjee, M, Sabir, S orcid.org/0000-0003-0611-6226 et al. (10 more authors) (2018) Mitotic spindle association of TACC3 requires Aurora‐A‐dependent stabilization of a cryptic α‐helix. EMBO Journal, 37 (8). e97902. ISSN 0261-4189

McIntyre, PJ, Collins, PM, Vrzal, L et al. (11 more authors) (2017) Characterization of three druggable hot-spots in the Aurora-A/TPX2 interaction using biochemical, biophysical and fragment-based approaches. ACS Chemical Biology, 12 (11). pp. 2906-2914. ISSN 1554-8929

Bayliss, R orcid.org/0000-0003-0604-2773, Burgess, SG, Leen, E et al. (1 more author) (2017) A moving target: structure and disorder in pursuit of Myc inhibitors. Biochemical Society Transactions, 45 (3). pp. 709-717. ISSN 0300-5127

Woo, CG, Seo, S, Kim, SW et al. (8 more authors) (2017) Differential protein stability and clinical responses of EML4 - ALKfusion variants to various ALK inhibitors in advanced ALK - rearranged non-small cell lung cancer. Annals of Oncology, 28 (4). mdw693. pp. 791-797. ISSN 0923-7534

Richards, MW orcid.org/0000-0003-1108-2825, Burgess, S orcid.org/0000-0003-0361-0691, Poon, E et al. (4 more authors) (2016) Structural basis of N-Myc binding by Aurora-A and its destabilization by kinase inhibitors. Proceedings of the National Academy of Sciences, 113 (48). pp. 13726-13731. ISSN 0027-8424

Burgess, SG orcid.org/0000-0003-0361-0691, Oleksy, A, Cavazza, T et al. (4 more authors) (2016) Allosteric inhibition of Aurora-A kinase by a synthetic vNAR domain. Open Biology, 6 (7). 160089. ISSN 2046-2441

Bachmann, G, Richards, MW, Winter, A et al. (3 more authors) (2016) A closed conformation of the Caenorhabditis elegans separase-securin complex. Open Biology, 6 (4). ISSN 2046-2441

Bayliss, R orcid.org/0000-0003-0604-2773, Choi, J, Fennell, DA et al. (2 more authors) (2016) Molecular mechanisms that underpin EML4-ALK driven cancers and their response to targeted drugs. Cellular and Molecular Life Sciences, 73 (6). pp. 1209-1224. ISSN 1420-682X

Proceedings Paper

Mukherjee, M, Sampson, J, Sabir, S et al. (8 more authors) (2017) Mitotic phosphorylation of Hsp72 uncouples ATP binding from substrate release and clusters amplified centrosomes in cancer cells. In: Molecular Biology of the Cell. ASCB | EMBO 2017 Meeting, 02-06 Dec 2017, Philadelphia, PA. American Society for Cell Biology , T-361-T-362.

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