Items where authors include "Radford, S.E."

Article

Willis, L.F., Brockwell, D.J. and Radford, S.E. orcid.org/0000-0002-3079-8039 (2025) In the Flow, How Fluid Dynamics Shapes Amyloid Formation. Proceedings of the National Academy of Sciences. ISSN 0027-8424 (In Press)

Taylor, A.I.P., Xu, Y., Wilkinson, M. et al. (7 more authors) (2025) Kinetic Steering of Amyloid Formation and Polymorphism by Canagliflozin, a Type-2 Diabetes Drug. Journal of the American Chemical Society. ISSN 0002-7863

Aubrey, L.D. and Radford, S.E. orcid.org/0000-0002-3079-8039 (2025) How is the Amyloid Fold Built? Polymorphism and the Microscopic Mechanisms of Fibril Assembly. Journal of Molecular Biology. 169008. ISSN 0022-2836

Willis, L.F. orcid.org/0000-0001-6616-3716, Trayton, I., Saunders, J.C. et al. (11 more authors) (2025) Rationalising mAb candidate screening using a single holistic developability parameter. Molecular Pharmaceutics, 22 (1). pp. 181-195. ISSN 1543-8384

Willis, L.F. orcid.org/0000-0001-6616-3716, Kapur, N. orcid.org/0000-0003-1041-8390, Radford, S.E. orcid.org/0000-0002-3079-8039 et al. (1 more author) (2024) Biophysical Analysis of Therapeutic Antibodies in the Early Development Pipeline. Biologics: Targets and Therapy, 18. pp. 413-432. ISSN 1177-5475

Serpell, L.C., Otzen, D.E. and Radford, S.E. orcid.org/0000-0002-3079-8039 (2024) Expanding the Protein Universe. Journal of Molecular Biology, 436 (21). 168812. ISSN 0022-2836

Schiffrin, R. orcid.org/0000-0002-1670-7356, Crossley, J.A. orcid.org/0000-0002-6656-1578, Walko, M. et al. (9 more authors) (2024) Dual client binding sites in the ATP-independent chaperone SurA. Nature Communications, 15. 8071. ISSN 2041-1723

Fenn, K.L. orcid.org/0000-0003-0638-2241, Horne, J.E. orcid.org/0000-0001-5260-2634, Crossley, J.A. orcid.org/0000-0002-6656-1578 et al. (6 more authors) (2024) Outer membrane protein assembly mediated by BAM-SurA complexes. Nature Communications, 15. 7612. ISSN 2041-1723

Dewison, K.M. orcid.org/0000-0002-7196-7687, Rowlinson, B., Machin, J.M. et al. (9 more authors) (2024) Residues 2-7 of α-synuclein regulate amyloid formation via lipid-dependent and -independent pathways. Proceedings of the National Academy of Sciences, 121 (34). e2315006121. ISSN 0027-8424

Berhanu, S., Majumder, S., Müntener, T. et al. (13 more authors) (2024) Sculpting conducting nanopore size and shape through de novo protein design. Science, 385 (6706). pp. 282-288. ISSN 0036-8075

Gilbert, M.A.G., Fatima, N., Jenkins, J. et al. (11 more authors) (2024) CryoET of β-amyloid and tau within postmortem Alzheimer’s disease brain. Nature, 631. pp. 913-919. ISSN 0028-0836

Gialama, D., Vadukul, D.M., Thrush, R.J. et al. (2 more authors) (2024) A Potent Sybody Selectively Inhibits α-Synuclein Amyloid Formation by Binding to the P1 Region. Journal of Medicinal Chemistry, 67 (12). pp. 9857-9868. ISSN 0022-2623

Santos, J., Cuellar, J., Pallares, I. et al. (15 more authors) (2024) A Targetable N-Terminal Motif Orchestrates α-Synuclein Oligomer-to-Fibril Conversion. Journal of the American Chemical Society, 146 (18). pp. 12702-12711. ISSN 0002-7863

Willis, L.F. orcid.org/0000-0001-6616-3716, Toprani, V., Wijetunge, S. et al. (7 more authors) (2024) Exploring a Role for Flow-Induced Aggregation Assays in Platform Formulation Optimisation for Antibody-Based Proteins. Journal of Pharmaceutical Sciences, 113 (3). pp. 625-636. ISSN 0022-3549

Louros, N. orcid.org/0000-0002-4030-1022, Wilkinson, M. orcid.org/0000-0001-5490-613X, Tsaka, G. et al. (14 more authors) (2024) Local structural preferences in shaping tau amyloid polymorphism. Nature Communications, 15. 1028. ISSN 2041-1723

Aubrey, L.D. orcid.org/0000-0003-0420-8274, Ninkina, N. orcid.org/0000-0001-8570-5648, Ulamec, S.M. orcid.org/0000-0002-9415-753X et al. (16 more authors) (2024) Substitution of Met-38 to Ile in γ-synuclein found in two patients with amyotrophic lateral sclerosis induces aggregation into amyloid. Proceedings of the National Academy of Sciences, 121 (2). e2309700120. ISSN 0027-8424

Crossley, J.A. orcid.org/0000-0002-6656-1578, Allen, W.J. orcid.org/0000-0002-9513-4786, Watkins, D.W. orcid.org/0000-0003-3825-5036 et al. (5 more authors) (2024) Dynamic coupling of fast channel gating with slow ATP-turnover underpins protein transport through the Sec translocon. The EMBO Journal, 43 (1). pp. 1-13.

Wilkinson, M., Xu, Y., Thacker, D. et al. (5 more authors) (2023) Structural evolution of fibril polymorphs during amyloid assembly. Cell, 186 (26). 5798-5811.e26. ISSN 0092-8674

Machin, J.M. orcid.org/0000-0002-1920-149X, Kalli, A.C. orcid.org/0000-0001-7156-9403, Ranson, N.A. orcid.org/0000-0002-3640-5275 et al. (1 more author) (2023) Protein–lipid charge interactions control the folding of outer membrane proteins into asymmetric membranes. Nature Chemistry, 15 (12). pp. 1754-1764. ISSN 1755-4330

Haysom, S.F., Machin, J., Whitehouse, J.M. et al. (9 more authors) (2023) Darobactin B Stabilises a Lateral-Closed Conformation of the BAM Complex in E. coli Cells. Angewandte Chemie, 135 (34). e202218783. ISSN 0044-8249

Rose, R.J., Verger, D., Daviter, T. et al. (5 more authors) (2008) Unraveling the molecular basis of subunit specificity in P pilus assembly by mass spectrometry. Proceedings of the National Academy of Sciences of The United States of America, 105 (35). pp. 12873-12878.

Jahn, T.R., Tennent, G.A. and Radford, S.E. (2008) A common beta-sheet architecture underlies in vitro and in vivo beta(2)-microglobulin amyloid fibrils. Journal of Biological Chemistry, 283 (25). pp. 17279-17286. ISSN 1083-351X

Paci, E., Rose, R.J., Welsh, T.S. et al. (3 more authors) (2008) Donor-strand exchange in chaperone-assisted pilus assembly revealed in atomic detail by molecular dynamics. Journal of Molecular Biology, 375 (4). pp. 908-919. ISSN 0022-2836

Smith, A.M., Jahn, T.R., Ashcroft, A.E. et al. (1 more author) (2006) Direct observation of oligomeric species formed in the early stages of amyloid fibril formation using mass spectrometry. Journal of Molecular Biology, 364 (1). pp. 9-19. ISSN 0022-2836

Borysik, A.J.H., Radford, S.E. and Ashcroft, A.E. (2004) Co-populated Conformational Ensembles of β(2)-Microglobulin Uncovered Quantitatively by Electrospray Ionization Mass Spectrometry. Journal of Biological Chemistry, 279 (26). pp. 27069-27077. ISSN 1083-351X

Gidalevitz, T., Biswas, C., Ding, H. et al. (5 more authors) (2004) Identification of the N-terminal Peptide Binding Site of Glucose-regulated Protein 94. Journal of Biological Chemistry, 279 (16). pp. 16543-16552. ISSN 1083-351X

Dimitriadis, G., Drysdale, A., Myers, J.K. et al. (4 more authors) (2004) Microsecond folding dynamics of the F13W G29A mutant of the B domain of staphylococcal protein A by laser-induced temperature jump. Proceedings of the National Academy of Sciences, 101 (11). pp. 3809-3814. ISSN 0027-8424

Smith, D.A., Brockwell, D.J., Zinober, R.C. et al. (4 more authors) (2003) Unfolding dynamics of proteins under applied force. Philosophical Transactions Of The Royal Society Of London Series A - Mathematical Physical and Engineering Sciences, 361 (1805). 713 -730. ISSN 1471-2962

Ashcroft, A.E., Brinker, A., Coyle, J.E. et al. (8 more authors) (2002) Structural Plasticity and Noncovalent Substrate Binding in the GroEL Apical Domain. A study using electrospray ionization mass spectrometry and fluorescence binding studies. Journal of Biological Chemistry, 277 (36). 33115-33126. ISSN 1083-351X

Trinh, C.H., Smith, D.P., Arnout, P.K. et al. (2 more authors) (2002) Crystal structure of monomeric human β-2- microglobulin reveals clues to its amyloidogenic properties. Proceedings of the National Academy of Sciences, 99 (15). pp. 9771-9776. ISSN 0027-8424

Other

Haysom, S.F., Machin, J., Whitehouse, J.M. et al. (9 more authors) (2023) Inside Cover: Darobactin B Stabilises a Lateral-Closed Conformation of the BAM Complex in E. coli Cells (Angew. Chem. Int. Ed. 34/2023). Wiley.