Items where authors include "Jemth, A.-S."

Article

Scaletti, E.R., Unterlass, J.E., Almlöf, I. et al. (7 more authors) (2024) Kinetic and structural characterization of NUDT15 and NUDT18 as catalysts of isoprene pyrophosphate hydrolysis. The FEBS Journal, 291 (19). pp. 4301-4322. ISSN 1742-464X

Zhang, S.M., Paulin, C.B.J., Shu, H. et al. (24 more authors) (2024) Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel. iScience, 27 (2). 108907. ISSN 2589-0042

Green, A.C. orcid.org/0000-0002-0175-1485, Marttila, P. orcid.org/0000-0002-0115-8067, Kiweler, N. orcid.org/0000-0001-7493-703X et al. (31 more authors) (2023) Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells. Nature Metabolism, 5 (4). pp. 642-659. ISSN 2522-5812

Scaletti, E., Gustafsson Westergren, R., Andersson, Y. et al. (6 more authors) (2022) The first structure of human MTHFD2L and its implications for the development of isoform‐selective inhibitors. ChemMedChem, 17 (18). e202200274. ISSN 1860-7179

Jemth, A.-S., Scaletti, E.R., Homan, E. et al. (3 more authors) (2022) Nudix hydrolase 18 catalyzes the hydrolysis of active triphosphate metabolites of the antivirals remdesivir, ribavirin, and molnupiravir. Journal of Biological Chemistry, 298 (8). 102169. ISSN 0021-9258

Rehling, D., Zhang, S.M., Jemth, A.-S. et al. (15 more authors) (2021) Crystal structures of NUDT15 variants enabled by a potent inhibitor reveal the structural basis for thiopurine sensitivity. Journal of Biological Chemistry, 296. 100568. ISSN 0021-9258

Visnes, T., Benítez-Buelga, C., Cázares-Körner, A. et al. (43 more authors) (2020) Targeting OGG1 arrests cancer cell proliferation by inducing replication stress. Nucleic Acids Research, 48 (21). pp. 12234-12251. ISSN 0305-1048

Zhang, S.M., Desroses, M., Hagenkort, A. et al. (34 more authors) (2020) Development of a chemical probe against NUDT15. Nature Chemical Biology, 16 (10). pp. 1120-1128. ISSN 1552-4450

Scaletti, E.R., Vallin, K.S., Bräutigam, L. et al. (5 more authors) (2020) MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool. Journal of Biological Chemistry, 295 (15). pp. 4761-4772. ISSN 0021-9258

Jemth, A.-S. orcid.org/0000-0002-7550-1833, Scaletti, E., Carter, M. et al. (2 more authors) (2019) Crystal structure and substrate specificity of the 8-oxo-dGTP hydrolase NUDT1 from Arabidopsis thaliana. Biochemistry, 58 (7). pp. 887-899. ISSN 0006-2960

Carter, M., Jemth, A.-S., Carreras-Puigvert, J. et al. (6 more authors) (2018) Human NUDT22 is a UDP-glucose/galactose hydrolase exhibiting a unique structural fold. Structure, 26 (2). 295-303.e6. ISSN 0969-2126

Page, B.D.G., Valerie, N.C.K., Wright, R.H.G. et al. (22 more authors) (2018) Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells. Nature Communications, 9 (1). 250. ISSN 2041-1723

Carreras-Puigvert, J., Zitnik, M., Jemth, A.-S. et al. (21 more authors) (2017) A comprehensive structural, biochemical and biological profiling of the human NUDIX hydrolase family. Nature Communications, 8 (1). 1541. ISSN 2041-1723

Hagenkort, A., Paulin, C.B.J., Desroses, M. et al. (12 more authors) (2017) dUTPase inhibition augments replication defects of 5-Fluorouracil. Oncotarget, 8 (14). pp. 23713-23726.

Valerie, N.C.K., Hagenkort, A., Page, B.D.G. et al. (10 more authors) (2016) NUDT15 hydrolyzes 6-thio-deoxyGTP to mediate the anticancer efficacy of 6-thioguanine. Cancer Research, 76 (18). pp. 5501-5511. ISSN 0008-5472

Carter, M., Jemth, A.-S., Hagenkort, A. et al. (10 more authors) (2015) Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2. Nature Communications, 6. 7871.