Items where authors include "Fletcher, A.G."

Article

Trinidad, L., Fletcher, A.G. orcid.org/0000-0003-0525-4336 and Strutt, D. orcid.org/0000-0001-8185-4515 (2025) The Fat-Dachsous planar polarity pathway competes with hinge contraction to orient polarized cell behaviors during Drosophila wing morphogenesis. Current Biology, 35 (2). 422-430.e3. ISSN 0960-9822

Cammarota, C., Dawney, N.S., Bellomio, P.M. et al. (4 more authors) (2024) The mechanical influence of densification on epithelial architecture. PLOS Computational Biology, 20 (4). e1012001. ISSN 1553-734X

Groves, I. orcid.org/0000-0001-6317-8226, Holmshaw, J., Furley, D. et al. (6 more authors) (2023) Accurate staging of chick embryonic tissues via deep learning of salient features. Development, 150 (22). dev202068. ISSN 0950-1991

Strawbridge, S.E. orcid.org/0000-0003-0273-0835, Kurowski, A. orcid.org/0000-0003-0502-571X, Corujo-Simon, E. orcid.org/0000-0002-5490-369X et al. (3 more authors) (2023) insideOutside: an accessible algorithm for classifying interior and exterior points, with applications in embryology. Biology Open, 12 (9). bio060055. ISSN 2046-6390

Montes-Olivas, S. orcid.org/0000-0002-7415-3558, Legge, D. orcid.org/0000-0002-3897-5861, Lund, A. et al. (4 more authors) (2023) In-silico and in-vitro morphometric analysis of intestinal organoids. PLOS Computational Biology, 19 (8). e1011386. ISSN 1553-734X

Schmidt, A., Finegan, T., Häring, M. et al. (6 more authors) (2023) Polychaetoid/ZO-1 strengthens cell junctions under tension while localizing differently than core adherens junction proteins. Molecular Biology of the Cell, 34 (8). ar81. ISSN 1059-1524

Johnson, C.G.M., Fletcher, A.G. orcid.org/0000-0003-0525-4336 and Soyer, O.S. (2022) ChemChaste : simulating spatially inhomogeneous biochemical reaction–diffusion systems for modeling cell–environment feedbacks. GigaScience, 11 (2022). ISSN 2047-217X

Nestor-Bergmann, A., Blanchard, G.B., Hervieux, N. et al. (3 more authors) (2022) Adhesion-regulated junction slippage controls cell intercalation dynamics in an Apposed-Cortex Adhesion Model. PLoS Computational Biology, 18 (1). e1009812. ISSN 1553-734X

Fletcher, A.G. orcid.org/0000-0003-0525-4336 and Osborne, J.M. (2022) Seven challenges in the multiscale modeling of multicellular tissues. WIREs Mechanisms of Disease, 14 (1). e1527. ISSN 2692-9368

Niehus, R., Oliveira, N.M., Li, A. et al. (2 more authors) (2021) The evolution of strategy in bacterial warfare via the regulation of bacteriocins and antibiotics. eLife, 10. e69756.

Gonay, L., Spourquet, C., Baudoin, M. et al. (5 more authors) (2021) Modelling of epithelial growth, fission and lumen formation during embryonic thyroid development : a combination of computational and experimental approaches. Frontiers in Endocrinology, 12. 655862.

Ruske, L.J., Kursawe, J., Tsakiridis, A. orcid.org/0000-0002-2184-2990 et al. (4 more authors) (2020) Coupled differentiation and division of embryonic stem cells inferred from clonal snapshots. Physical Biology, 17 (6). 065009. ISSN 1478-3967

Campbell, K., Noël, E.S., Fletcher, A.G. orcid.org/0000-0003-0525-4336 et al. (1 more author) (2020) Contemporary morphogenesis. Philosophical Transactions of the Royal Society B: Biological Sciences, 375 (1809). 20190549. ISSN 0962-8436

Groves, I., Placzek, M. and Fletcher, A.G. orcid.org/0000-0003-0525-4336 (2020) Of mitogens and morphogens : modelling Sonic Hedgehog mechanisms in vertebrate development. Philosophical Transactions of the Royal Society B: Biological Sciences, 375 (1809). 20190660. ISSN 0962-8436

Gorochowski, T.E., Hauert, S., Kreft, J.-U. et al. (17 more authors) (2020) Toward engineering biosystems with emergent collective functions. Frontiers in Bioengineering and Biotechnology, 8. 705. ISSN 2296-4185

Grimes, D.R. and Fletcher, A.G. orcid.org/0000-0003-0525-4336 (2020) Close encounters of the cell kind: The impact of contact inhibition on tumour growth and cancer models. Bulletin of Mathematical Biology, 82 (2). 20. ISSN 0092-8240

Finegan, T.M., Hervieux, N., Nestor-Bergmann, A. et al. (3 more authors) (2019) The tricellular vertex-specific adhesion molecule sidekick facilitates polarised cell intercalation during drosophila axis extension. PLOS Biology, 17 (12). e3000522. ISSN 1544-9173

Cooper, R.L., Lloyd, V.J., Di-Poï, N. et al. (3 more authors) (2019) Conserved gene signalling and a derived patterning mechanism underlie the development of avian footpad scales. EvoDevo, 10 (1). 19.

Scott, J.G., Maini, P.K., Anderson, A.R.A. et al. (1 more author) (2019) Inferring tumour proliferative organisation from phylogenetic tree measures in a computational model. Systematic Biology. pp. 1-41. ISSN 1063-5157

Blanchard, G.B., Fletcher, A.G. orcid.org/0000-0003-0525-4336 and Schumacher, L.J. (2019) The devil is in the mesoscale: mechanical and behavioural heterogeneity in collective cell movement. Seminars in Cell & Developmental Biology, 93. pp. 46-54.

Fisher, K.H., Strutt, D. orcid.org/0000-0001-8185-4515 and Fletcher, A.G. orcid.org/0000-0003-0525-4336 (2019) Experimental and theoretical evidence for bidirectional signaling via core planar polarity protein complexes in Drosophila. iScience, 17. pp. 49-66. ISSN 2589-0042

Baker, A.-M., Cereser, B., Melton, S. et al. (10 more authors) (2019) Quantification of crypt and stem cell evolution in the normal and neoplastic human colon. Cell Reports, 27 (8). p. 2524. ISSN 2211-1247

Scott, J.G., Dhawan, A., Hjelmeland, A. et al. (6 more authors) (2019) Recasting the cancer stem cell hypothesis: Unification using a continuum model of microenvironmental forces. Current Stem Cell Reports, 5 (1). pp. 22-30. ISSN 2198-7866

Parker, A., Vaux, L., Patterson, A.M. et al. (7 more authors) (2019) Elevated apoptosis impairs epithelial cell turnover and shortens villi in TNF-driven intestinal inflammation. Cell Death and Disease, 10. 108. ISSN 2041-4889

Finegan, T.M., Na, D., Cammarota, C. et al. (6 more authors) (2018) Tissue tension and not interphase cell shape determines cell division orientation in the Drosophila follicular epithelium. EMBO Journal, 37 (23). e100072. ISSN 0261-4189

Scott, J.G. orcid.org/0000-0003-2971-7673, Maini, P.K. orcid.org/0000-0002-0146-9164, Anderson, A.R.A. orcid.org/0000-0002-2536-4383 et al. (1 more author) (2018) Inferring tumour proliferative organisation from phylogenetic tree measures in a computational model. bioRxiv. (Submitted)

Cooper, R., Thiery, A., Fletcher, A.G. orcid.org/0000-0003-0525-4336 et al. (3 more authors) (2018) An ancient Turing-like patterning mechanism regulates skin denticle development in sharks. Science Advances, 4 (11). eaau5484. ISSN 2375-2548

Muraro, D. orcid.org/0000-0001-9601-237X, Parker, A., Vaux, L. et al. (7 more authors) (2018) Chronic TNFα-driven injury delays cell migration to villi in the intestinal epithelium. Interface, 15 (145). 20180037. ISSN 1742-5689

Lambert, B. orcid.org/0000-0003-4274-4158, MacLean, A.L., Fletcher, A.G. orcid.org/0000-0003-0525-4336 et al. (3 more authors) (2018) Bayesian inference of agent-based models: a tool for studying kidney branching morphogenesis. Journal of Mathematical Biology, 76 (7). pp. 1673-1697. ISSN 0303-6812

Kursawe, J., Baker, R.E. and Fletcher, A.G. orcid.org/0000-0003-0525-4336 (2018) Approximate Bayesian computation reveals the importance of repeated measurements for parameterising cell-based models of growing tissues. Journal of Theoretical Biology, 443. pp. 66-81. ISSN 0022-5193

Cooper, F., Baker, R.E. and Fletcher, A.G. orcid.org/0000-0003-0525-4336 (2017) Numerical Analysis of the Immersed Boundary Method for Cell-Based Simulation. SIAM Journal on Scientific Computing, 39 (5). B943-B967. ISSN 1064-8275

Fisher, K.H., Strutt, D. and Fletcher, A.G. orcid.org/0000-0003-0525-4336 (2017) Integrating planar polarity and tissue mechanics in computational models of epithelial morphogenesis. Current Opinion in Systems Biology, 5. pp. 41-49. ISSN 2452-3100

Kursawe, J., Baker, R.E. and Fletcher, A.G. (2017) Impact of implementation choices on quantitative predictions of cell-based computational models. Journal of Computational Physics, 345. pp. 752-767. ISSN 0021-9991

Godwin, S., Ward, D., Pedone, E. et al. (3 more authors) (2017) An extended model for culture-dependent heterogenous gene expression and proliferation dynamics in mouse embryonic stem cells. npj Systems Biology and Applications, 3. 19.

Maclaren, O.J. orcid.org/0000-0002-3982-4539, Parker, A., Pin, C. et al. (5 more authors) (2017) A hierarchical Bayesian model for understanding the spatiotemporal dynamics of the intestinal epithelium. PLoS Computational Biology, 13 (7). e1005688. ISSN 1553-734X

Bucksch, A., Atta-Boateng, A., Azihou, A.F. et al. (34 more authors) (2017) Morphological Plant Modeling: Unleashing Geometric and Topological Potential within the Plant Sciences. Frontiers in Plant Science, 8. 900.

Fletcher, A.G. orcid.org/0000-0003-0525-4336, Cooper, F. and Baker, R.E. (2017) Mechanocellular models of epithelial morphogenesis. Philosophical Transactions of the Royal Society B: Biological Sciences, 372 (1720). 20150519. ISSN 0962-8436

Osborne, J.M., Fletcher, A.G. orcid.org/0000-0003-0525-4336, Pitt-Francis, J.M. et al. (2 more authors) (2017) Comparing individual-based approaches to modelling the self-organization of multicellular tissues. PLoS Computational Biology, 13 (2). e1005387. ISSN 1553-734X

Parker, A., Maclaren, O.J., Fletcher, A.G. orcid.org/0000-0003-0525-4336 et al. (6 more authors) (2017) Cell proliferation within small intestinal crypts is the principal driving force for cell migration on villi. FASEB Journal, 31 (2). pp. 636-649. ISSN 1530-6860

Friedman, S.H. orcid.org/0000-0001-8003-6860, Anderson, A.R.A. orcid.org/0000-0002-2536-4383, Bortz, D.M. orcid.org/0000-0003-1163-7317 et al. (21 more authors) (2016) MultiCellDS : a community-developed standard for curating microenvironment-dependent multicellular data. bioRxiv. (Submitted)

Kursawe, J., Bardenet, R., Zartman, J.J. et al. (2 more authors) (2016) Robust cell tracking in epithelial tissues through identification of maximum common subgraphs. Interface, 13 (124). 20160725. ISSN 1742-5689

Tetley, R.J., Blanchard, G.B., Fletcher, A.G. orcid.org/0000-0003-0525-4336 et al. (2 more authors) (2016) Unipolar distributions of junctional Myosin II identify cell stripe boundaries that drive cell intercalation throughout Drosophila axis extension. eLife, 5.

Scott, J.G., Fletcher, A.G., Anderson, A.R. et al. (1 more author) (2016) Spatial Metrics of Tumour Vascular Organisation Predict Radiation Efficacy in a Computational Model. PLoS Computational Biology, 12 (1). e1004712. ISSN 1553-7358

Kursawe, J., Brodskiy, P.A., Zartman, J.J. et al. (2 more authors) (2015) Capabilities and Limitations of Tissue Size Control through Passive Mechanical Forces. PLoS Computational Biology, 11 (12). e1004679. ISSN 1553-7358

Fletcher, A.G., Murray, P.J. and Maini, P.K. (2015) Multiscale modelling of intestinal crypt organization and carcinogenesis. Mathematical Models and Methods in Applied Sciences , 25 (13). pp. 2563-2585. ISSN 0218-2025

Maclaren, O.J., Byrne, H.M., Fletcher, A.G. et al. (1 more author) (2015) Models, measurement and inference in epithelial tissue dynamics. Mathematical Biosciences and Engineering , 12 (6). pp. 1321-1340. ISSN 1547-1063

Niehus, R., Mitri, S., Fletcher, A.G. et al. (1 more author) (2015) Migration and horizontal gene transfer divide microbial genomes into multiple niches. Nature Communications, 6. 8924. ISSN 2041-1723

Nichol, D., Jeavons, P., Fletcher, A.G. et al. (6 more authors) (2015) Steering Evolution with Sequential Therapy to Prevent the Emergence of Bacterial Antibiotic Resistance. PLoS Computational Biology, 11 (9). e1004493. ISSN 1553-734X

Harvey, D.G., Fletcher, A.G., Osborne, J.M. et al. (1 more author) (2015) A parallel implementation of an off-lattice individual-based model of multicellular populations. Computer Physics Communications, 192. pp. 130-137. ISSN 0010-4655

Knapp, B., Bardenet, R., Bernabeu, M.O. et al. (17 more authors) (2015) Ten Simple Rules for a Successful Cross-Disciplinary Collaboration. PLoS Computational Biology, 11 (4). e1004214. ISSN 1553-734X

Grimes, D.R., Fletcher, A.G. orcid.org/0000-0003-0525-4336 and Partridge, M. (2014) Oxygen consumption dynamics in steady-state tumour models. R Soc Open Sci, 1 (1). 140080.

Osborne, J.M., Bernabeu, M.O., Bruna, M. et al. (17 more authors) (2014) Ten Simple Rules for Effective Computational Research. PLoS Computational Biology , 10 (3). e1003506. ISSN 1553-734X

Rosser, G., Fletcher, A.G. orcid.org/0000-0003-0525-4336, Wilkinson, D.A. et al. (5 more authors) (2013) Novel Methods for Analysing Bacterial Tracks Reveal Persistence in Rhodobacter sphaeroides. PLoS Computational Biology, 9 (10). e1003276. ISSN 1553-7358

Mirams, G.R., Arthurs, C.J., Bernabeu, M.O. et al. (14 more authors) (2013) Chaste: An Open Source C++ Library for Computational Physiology and Biology. PLoS Computational Biology, 9 (3). e1002970. ISSN 1553-734X

Preprint

Cammarota, C. orcid.org/0000-0002-7551-2460, Dawney, N.S. orcid.org/0000-0002-9972-3756, Bellomio, P.M. et al. (4 more authors) (2023) The mechanical influence of densification on initial epithelial architecture. [Preprint] (Submitted)