Items where authors include "Brockwell, D.J."

Article

Dewison, K.M., Taylor, A.I.P., Brockwell, D.J. et al. (1 more author) (2025) Mapping the role of monomer conformation in amyloid formation of α-synuclein splice variants. Journal of the American Chemical Society. ISSN 0002-7863 (In Press)

Byrd, E.J., Rowlinson, B., Crossley, J.A. et al. (4 more authors) (2025) Zn2+ Binding Shifts the Conformational Ensemble of α-Synuclein Monomers toward Accelerated Amyloid Formation. Journal of the American Chemical Society, 147 (40). pp. 36464-36477. ISSN 0002-7863

McKay, C.E. orcid.org/0009-0001-7357-5441, Deans, M., Connor, J. orcid.org/0000-0003-1465-8543 et al. (4 more authors) (2025) Employing deep mutational scanning in the Escherichia coli periplasm to decode the thermodynamic landscape for amyloid formation. Proceedings of the National Academy of Sciences of the United States of America, 122 (38). e2516165122. ISSN 0027-8424

Connor, J.P., Radford, S. and Brockwell, D.J. orcid.org/0000-0002-0802-5937 (2025) Structural and Thermodynamic Classification of Amyloid Polymorphs. Structure. ISSN 0969-2126 (In Press)

Willis, L.F., Brockwell, D.J. and Radford, S.E. orcid.org/0000-0002-3079-8039 (2025) In the flow, how fluid dynamics shapes amyloid formation. Proceedings of the National Academy of Sciences, 122 (16). e2504573122. ISSN 0027-8424

Laurent, H., Brockwell, D.J. orcid.org/0000-0002-0802-5937 and Dougan, L. orcid.org/0000-0002-2620-5827 (2025) Nanomachine Networks: Functional All-Enzyme Hydrogels from Photochemical Cross-Linking of Glucose Oxidase. Biomacromolecules, 26 (2). pp. 1195-1206. ISSN 1525-7797

Hughes, M.D.G. orcid.org/0000-0001-5838-7939, Cussons, S.E., Boroumand, A. orcid.org/0000-0002-4330-4691 et al. (3 more authors) (2025) Capturing the impact of protein unfolding on the dynamic assembly of protein networks. Soft Matter. ISSN 1744-683X

Hughes, M.D.G. orcid.org/0000-0001-5838-7939, West, D., Wurr, R. orcid.org/0000-0002-7127-5859 et al. (6 more authors) (2025) Competition between cross-linking and force-induced local conformational changes determines the structure and mechanics of labile protein networks. Journal of Colloid and Interface Science, 678 (Part C). pp. 1259-1269. ISSN 0021-9797

Hughes, M.D.G. orcid.org/0000-0001-5838-7939, Cook, K.R. orcid.org/0009-0008-5534-2813, Cussons, S. orcid.org/0000-0002-9318-3859 et al. (5 more authors) (2025) Capturing Dynamic Assembly of Nanoscale Proteins During Network Formation. Small, 21 (1). 2407090. ISSN 1613-6810

Willis, L.F. orcid.org/0000-0001-6616-3716, Trayton, I., Saunders, J.C. et al. (11 more authors) (2025) Rationalising mAb candidate screening using a single holistic developability parameter. Molecular Pharmaceutics, 22 (1). pp. 181-195. ISSN 1543-8384

Willis, L.F. orcid.org/0000-0001-6616-3716, Kapur, N. orcid.org/0000-0003-1041-8390, Radford, S.E. orcid.org/0000-0002-3079-8039 et al. (1 more author) (2024) Biophysical Analysis of Therapeutic Antibodies in the Early Development Pipeline. Biologics: Targets and Therapy, 18. pp. 413-432. ISSN 1177-5475

Schiffrin, R. orcid.org/0000-0002-1670-7356, Crossley, J.A. orcid.org/0000-0002-6656-1578, Walko, M. et al. (9 more authors) (2024) Dual client binding sites in the ATP-independent chaperone SurA. Nature Communications, 15. 8071. ISSN 2041-1723

Dewison, K.M. orcid.org/0000-0002-7196-7687, Rowlinson, B., Machin, J.M. et al. (9 more authors) (2024) Residues 2-7 of α-synuclein regulate amyloid formation via lipid-dependent and -independent pathways. Proceedings of the National Academy of Sciences, 121 (34). e2315006121. ISSN 0027-8424

Berhanu, S., Majumder, S., Müntener, T. et al. (13 more authors) (2024) Sculpting conducting nanopore size and shape through de novo protein design. Science, 385 (6706). pp. 282-288. ISSN 0036-8075

Willis, L.F. orcid.org/0000-0001-6616-3716, Toprani, V., Wijetunge, S. et al. (7 more authors) (2024) Exploring a Role for Flow-Induced Aggregation Assays in Platform Formulation Optimisation for Antibody-Based Proteins. Journal of Pharmaceutical Sciences, 113 (3). pp. 625-636. ISSN 0022-3549

Aubrey, L.D. orcid.org/0000-0003-0420-8274, Ninkina, N. orcid.org/0000-0001-8570-5648, Ulamec, S.M. orcid.org/0000-0002-9415-753X et al. (16 more authors) (2024) Substitution of Met-38 to Ile in γ-synuclein found in two patients with amyotrophic lateral sclerosis induces aggregation into amyloid. Proceedings of the National Academy of Sciences, 121 (2). e2309700120. ISSN 0027-8424

Laurent, H. orcid.org/0000-0002-8925-4773, Hughes, M.D.G. orcid.org/0000-0001-5838-7939, Walko, M. orcid.org/0000-0002-7160-6136 et al. (5 more authors) (2023) Visualization of Self-Assembly and Hydration of a β-Hairpin through Integrated Small and Wide-Angle Neutron Scattering. Biomacromolecules. ISSN 1525-7797

Smith, D.A., Brockwell, D.J., Zinober, R.C. et al. (4 more authors) (2003) Unfolding dynamics of proteins under applied force. Philosophical Transactions Of The Royal Society Of London Series A - Mathematical Physical and Engineering Sciences, 361 (1805). 713 -730. ISSN 1471-2962