Items where authors include "Beech, DJ"
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Endesh, N, Chuntharpursat-BON, E, Revill, C et al. (11 more authors) (2023) Independent endothelial functions of PIEZO1 and TRPV4 in hepatic portal vein and predominance of PIEZO1 in mechanical and osmotic stress. Liver International. ISSN 1478-3223
Chuntharpursat-Bon, E, Povstyan, OV, Ludlow, MJ et al. (17 more authors) (2023) PIEZO1 and PECAM1 interact at cell-cell junctions and partner in endothelial force sensing. Communications Biology, 6. 358. ISSN 2399-3642
Morley, LC orcid.org/0000-0002-1109-1396, Debant, M, Gaunt, HJ et al. (2 more authors) (2023) Nitric oxide synthase phosphorylation in fetoplacental endothelium is enhanced by agonism of Piezo1 mechanosensor in small for gestational age babies. Reproduction & Fertility, 4 (1). e220100. ISSN 2633-8386
Parsonage, G, Cuthbertson, K, Endesh, N et al. (16 more authors) (2022) Improved PIEZO1 agonism through 4-benzoic acid modification of Yoda1. British Journal of Pharmacology. ISSN 0007-1188
Masson, B, Le Ribeuz, H, Sabourin, J et al. (16 more authors) (2022) Orai1 Inhibitors as Potential Treatments for Pulmonary Arterial Hypertension. Circulation Research, 131 (9). e102-e119.. ISSN 0009-7330
Bartoli, F orcid.org/0000-0001-9487-9551, Evans, EL, Blythe, NM et al. (9 more authors) (2022) Global PIEZO1 Gain-of-Function Mutation Causes Cardiac Hypertrophy and Fibrosis in Mice. Cells, 11 (7). 1199. ISSN 2073-4409
Schremmer, C, Steinritz, D, Gudermann, T et al. (2 more authors) (2022) An ex vivo perfused ventilated murine lung model suggests lack of acute pulmonary toxicity of the potential novel anticancer agent (−)-englerin A. Archives of Toxicology, 96 (4). pp. 1055-1063. ISSN 0340-5761
Baradaran-Heravi, A, Bauer, CC, Pickles, IB et al. (7 more authors) (2022) Non-selective TRPC channel inhibition and suppression of aminoglycoside-induced premature termination codon readthrough by the small molecule AC1903. Journal of Biological Chemistry, 298 (2). 101546. p. 101546. ISSN 0021-9258
Bartoli, F, Debant, M, Chuntharpursat-Bon, E et al. (11 more authors) (2022) Endothelial Piezo1 sustains muscle capillary density and contributes to physical activity. The Journal of clinical investigation. ISSN 0021-9738
Bon, RS orcid.org/0000-0003-1733-3680, Wright, DJ, Beech, DJ orcid.org/0000-0002-7683-9422 et al. (1 more author) (2022) Pharmacology of TRPC Channels and Its Potential in Cardiovascular and Metabolic Medicine. Annual Review of Pharmacology and Toxicology, 62. pp. 427-446. ISSN 0362-1642
Viswambharan, H orcid.org/0000-0002-7616-5026, Yuldasheva, NY, Imrie, H et al. (22 more authors) (2021) Novel Paracrine Action of Endothelium enhances Glucose Uptake in Muscle and Fat. Circulation Research. ISSN 0009-7330
Walker, AMN orcid.org/0000-0003-0380-7283, Warmke, N, Mercer, B et al. (13 more authors) (2021) Endothelial Insulin Receptors Promote VEGF-A Signaling via ERK1/2 and Sprouting Angiogenesis. Endocrinology, 162 (8). bqab104. ISSN 0013-7227
Haywood, NJ orcid.org/0000-0002-8762-7257, Luk, C orcid.org/0000-0002-6828-5423, Bridge, KI et al. (20 more authors) (2021) Endothelial IGF‐1 receptor mediates crosstalk with the gut wall to regulate microbiota in obesity. EMBO Reports, 22 (5). e50767. ISSN 1469-221X
Chong, J orcid.org/0000-0002-5846-7397, De Vecchis, D, Hyman, AJ et al. (5 more authors) (2021) Modelling of full-length Piezo1 suggests importance of the proximal N-terminus for dome structure. Biophysical Journal, 120 (8). pp. 1343-1356. ISSN 0006-3495
De Vecchis, D, Beech, DJ orcid.org/0000-0002-7683-9422 and Kalli, AC orcid.org/0000-0001-7156-9403 (2021) Molecular dynamics simulations of Piezo1 channel opening by increases in membrane tension. Biophysical Journal, 120 (8). P1510-P1521. ISSN 0006-3495
Shawer, H, Norman, K, Cheng, CW orcid.org/0000-0002-2873-0828 et al. (3 more authors) (2021) ORAI1 Ca2+ channel as a therapeutic target in pathological vascular remodelling. Frontiers in Cell and Developmental Biology, 9. 653812. ISSN 2296-634X
Hendrickx, G, Fischer, V, Liedert, A et al. (14 more authors) (2021) Piezo1 Inactivation in Chondrocytes Impairs Trabecular Bone Formation. Journal of Bone and Mineral Research, 36 (2). pp. 369-384. ISSN 0884-0431
Morley, LC, Debant, M, Walker, JJ et al. (2 more authors) (2021) Placental blood flow sensing and regulation in fetal growth restriction. Placenta. ISSN 0143-4004
Wright, DJ, Simmons, KJ, Johnson, RM et al. (3 more authors) (2020) Human TRPC5 structures reveal interaction of a xanthine-based TRPC1/4/5 inhibitor with a conserved lipid binding site. Communications Biology, 3 (1). 704. ISSN 2399-3642
Shi, J, Hyman, AJ, De Vecchis, D et al. (8 more authors) (2020) Sphingomyelinase Disables Inactivation in Endogenous PIEZO1 Channels. Cell Reports, 33 (1). 108225. ISSN 2211-1247
Cheng, CW orcid.org/0000-0002-2873-0828, Beech, DJ orcid.org/0000-0002-7683-9422 and Wheatcroft, SB orcid.org/0000-0002-6741-9012 (2020) Advantages of CEMiTool for gene co-expression analysis of RNA-seq data. Computers in Biology and Medicine, 125. 103975. ISSN 0010-4825
Beech, DJ and Lichtenstein, L orcid.org/0000-0003-3900-786X (2020) RNA and the PIEZO force sensor. Cell Research, 30 (10). pp. 829-830. ISSN 1001-0602
Bauer, CC, Minard, A, Pickles, IB et al. (9 more authors) (2020) Xanthine-based photoaffinity probes allow assessment of ligand engagement by TRPC5 channels. RSC Chemical Biology. ISSN 2633-0679
Wu, Z, Suppo, J-S, Tumova, S et al. (10 more authors) (2020) Bridgehead Modifications of Englerin A Reduce TRPC4 Activity and Intravenous Toxicity but not Cell Growth Inhibition. ACS Medicinal Chemistry Letters, 11 (9). pp. 1711-1716. ISSN 1948-5875
Caspi, T, Straw, S orcid.org/0000-0002-2942-4574, Cheng, C orcid.org/0000-0002-2873-0828 et al. (14 more authors) (2020) Unique Transcriptome Signature Distinguishes Patients With Heart Failure With Myopathy. Journal of the American Heart Association. ISSN 2047-9980
Benitah, J-P, Beech, DJ and Sabourin, J (2020) Response by Benitah et al to Letter Regarding Article, “Orai1 Channel Inhibition Preserves Left Ventricular Systolic Function and Normal Ca2+ Handling After Pressure Overload”. Circulation, 141 (22). e839-e840. ISSN 0009-7322
Caolo, V orcid.org/0000-0001-6215-2702, Debant, M, Endesh, N et al. (6 more authors) (2020) Shear stress activates ADAM10 sheddase to regulate Notch1 via the Piezo1 force sensor in endothelial cells. eLife, 9. ISSN 2050-084X
Maqbool, A, Watt, N, Haywood, N et al. (17 more authors) (2020) Divergent effects of genetic and pharmacological inhibition of Nox2 NADPH oxidase on insulin resistance related vascular damage. American Journal of Physiology: Cell Physiology. ISSN 0363-6143
Evans, EL, Povstyan, OV, De Vecchis, D orcid.org/0000-0002-7732-5095 et al. (9 more authors) (2020) RBCs prevent rapid PIEZO1 inactivation and expose slow deactivation as a mechanism of DHS. Blood. ISSN 0006-4971
Bartoli, F orcid.org/0000-0001-9487-9551, Bailey, MA orcid.org/0000-0001-5038-1970, Rode, B et al. (23 more authors) (2020) Orai1 Channel Inhibition Preserves Left Ventricular Systolic Function and Normal Ca2+ Handling After Pressure Overload. Circulation, 141 (3). pp. 199-216. ISSN 0009-7322
Blythe, NM, Muraki, K, Ludlow, MJ et al. (12 more authors) (2019) Mechanically activated Piezo1 channels of cardiac fibroblasts stimulate p38 mitogen-activated protein kinase activity and interleukin-6 secretion. Journal of Biological Chemistry, 294 (46). pp. 17395-17408. ISSN 0021-9258
Deivasikamani, V, Dhayalan, S, Abudushalamu, Y et al. (12 more authors) (2019) Piezo1 channel activation mimics high glucose as a stimulator of insulin release. Scientific Reports, 9. 16876. ISSN 2045-2322
Beech, DJ and Kalli, AC orcid.org/0000-0001-7156-9403 (2019) Force Sensing by Piezo Channels in Cardiovascular Health and Disease. Arteriosclerosis, Thrombosis, and Vascular Biology, 39 (11). pp. 2228-2239. ISSN 1079-5642
Minard, A, Bauer, CC, Chuntharpursat-Bon, E et al. (8 more authors) (2019) Potent, selective, and subunit‐dependent activation of TRPC5 channels by a xanthine derivative. British Journal of Pharmacology, 176 (20). pp. 3924-3938. ISSN 0007-1188
Miteva, KT, Pedicini, L, Wilson, LA et al. (9 more authors) (2019) Rab46 integrates Ca2+ and histamine signaling to regulate selective cargo release from Weibel-Palade bodies. Journal of Cell Biology, 218 (7). pp. 2232-2246. ISSN 0021-9525
Morley, LC, Beech, DJ, Walker, JJ orcid.org/0000-0002-8922-083X et al. (1 more author) (2019) Emerging concepts of shear stress in placental development and function. Molecular Human Reproduction, 25 (6). pp. 329-339. ISSN 1360-9947
Rode, B, Yuldasheva, NY orcid.org/0000-0001-6213-6358, Baxter, PD orcid.org/0000-0003-2699-3103 et al. (7 more authors) (2019) TRPC5 ion channel permeation promotes weight gain in hypercholesterolaemic mice. Scientific Reports, 9. 773. ISSN 2045-2322
Beech, DJ (2019) Triskelion channels might bring Star Wars to the global problem of hypertension. Cell Calcium, 77. pp. 77-78. ISSN 0143-4160
Thakore, P, Brain, SD and Beech, DJ (2018) Correspondence: Challenging a proposed role for TRPC5 in aortic baroreceptor pressure-sensing. Nature Communications, 9 (1). 1245. ISSN 2041-1723
Morley, LC, Shi, J, Gaunt, HJ et al. (7 more authors) (2018) Piezo1 channels are mechanosensors in human fetoplacental endothelial cells. Molecular Human Reproduction, 24 (10). pp. 510-520. ISSN 1360-9947
Lepannetier, S, Gualdani, R, Tempesta, S et al. (12 more authors) (2018) Activation of TRPC1 Channel by Metabotropic Glutamate Receptor mGluR5 Modulates Synaptic Plasticity and Spatial Working Memory. Frontiers in Cellular Neuroscience, 12. e318. ISSN 1662-5102
Rubaiy, HN orcid.org/0000-0002-1489-5576, Ludlow, MJ, Siems, K et al. (5 more authors) (2018) Tonantzitlolone is a Nanomolar Potency Activator of TRPC1/4/5 Channels. British Journal of Pharmacology, 175 (16). pp. 3361-3368. ISSN 0007-1188
Cheung, SY, Henrot, M, Al-Saad, M et al. (17 more authors) (2018) TRPC4/TRPC5 channels mediate adverse reaction to the cancer cell cytotoxic agent (-)-Englerin A. Oncotarget, 9 (51). pp. 29634-29643. ISSN 1949-2553
Rode, B, Bailey, MA orcid.org/0000-0001-5038-1970, Marthan, R et al. (2 more authors) (2018) ORAI Channels as Potential Therapeutic Targets in Pulmonary Hypertension. Physiology, 33 (4). pp. 261-268. ISSN 1548-9213
Minard, A, Bauer, CC, Wright, DJ et al. (4 more authors) (2018) Remarkable Progress with Small-Molecule Modulation of TRPC1/4/5 Channels: Implications for Understanding the Channels in Health and Disease. Cells, 7 (6). 52. ISSN 2073-4409
Pedicini, L, Miteva, KT, Hawley, V et al. (7 more authors) (2018) Homotypic endothelial nanotubes induced by wheat germ agglutinin and thrombin. Scientific Reports, 8. 7569. ISSN 2045-2322
Evans, EL, Cuthbertson, K, Endesh, N et al. (8 more authors) (2018) Yoda1 analogue (Dooku1) which antagonizes Yoda1‐evoked activation of Piezo1 and aortic relaxation. British Journal of Pharmacology, 175 (10). pp. 1744-1759. ISSN 0007-1188
Beech, DJ (2018) Endothelial Piezo1 channels as sensors of exercise. Journal of Physiology, 596 (6). pp. 979-984. ISSN 0022-3751
Beech, DJ and Xiao, B (2018) Piezo channel mechanisms in health and disease. The Journal of Physiology, 596 (6). pp. 965-967. ISSN 0022-3751
Rubaiy, HN orcid.org/0000-0002-1489-5576, Seitz, T, Hahn, S et al. (8 more authors) (2018) Identification of an (−)‐englerin A analogue, which antagonizes (−)‐englerin A at TRPC1/4/5 channels. British Journal of Pharmacology, 175 (5). pp. 830-839. ISSN 0007-1188
Muraki, K, Ohnishi, K, Takezawa, A et al. (10 more authors) (2017) Na⁺ entry through heteromeric TRPC4/C1 channels mediates (-)Englerin A-induced cytotoxicity in synovial sarcoma cells. Scientific Reports, 7 (1). 16988. ISSN 2045-2322
Webster, PJ, Littlejohns, AT, Gaunt, HJ et al. (3 more authors) (2017) AZD1775 Induces Toxicity Through Double-Stranded DNA Breaks Independently of Chemotherapeutic Agents in p53-Mutated Colorectal Cancer Cells. Cell Cycle, 16 (22). pp. 2176-2182. ISSN 1538-4101
Watt, NT, Gage, MC, Patel, PA et al. (15 more authors) (2017) Endothelial SHIP2 Suppresses Nox2 NADPH Oxidase–Dependent Vascular Oxidative Stress, Endothelial Dysfunction, and Systemic Insulin Resistance. Diabetes, 66 (11). pp. 2808-2821. ISSN 0012-1797
Rubaiy, HN orcid.org/0000-0002-1489-5576, Ludlow, MJ, Bon, RS orcid.org/0000-0003-1733-3680 et al. (1 more author) (2017) Pico145 - powerful new tool for TRPC1/4/5 channels. Channels, 11 (5). pp. 362-364. ISSN 1933-6950
Rode, B, Shi, J, Endesh, N et al. (22 more authors) (2017) Piezo1 channels sense whole body physical activity to reset cardiovascular homeostasis and enhance performance. Nature Communications, 8. 350. ISSN 2041-1723
Rubaiy, HN orcid.org/0000-0002-1489-5576, Ludlow, MJ, Henrot, M et al. (18 more authors) (2017) Picomolar, selective, and subtype-specific small-molecule inhibition of TRPC1/4/5 channels. Journal of Biological Chemistry, 292 (20). pp. 8158-8173. ISSN 0021-9258
Webster, PJ, Littlejohns, AT, Beech, DJ et al. (1 more author) (2017) AZD1775 induces toxicity through double-stranded DNA breaks independent of 5-FU activity in P53 mutated colorectal cancer cells. British Journal of Surgery, 104 (S3). pp. 43-44. ISSN 0007-1323
Viswambharan, VH orcid.org/0000-0002-7616-5026, Yuldasheva, NY orcid.org/0000-0001-6213-6358, Sengupta, A et al. (18 more authors) (2017) Selective Enhancement of Insulin Sensitivity in the Endothelium In Vivo Reveals a Novel Proatherosclerotic Signaling Loop. Circulation Research, 120 (5). pp. 784-798. ISSN 0009-7330
Webster, PJ, Littlejohns, AT, Gaunt, HJ et al. (17 more authors) (2017) Upregulated WEE1 protects endothelial cells of colorectal cancer liver metastases. Oncotarget, 8 (26). pp. 42288-42299. ISSN 1949-2553
Ludlow, MJ, Gaunt, HJ, Rubaiy, HN orcid.org/0000-0002-1489-5576 et al. (5 more authors) (2017) (-)-Englerin A-evoked Cytotoxicity is Mediated by Na+ Influx and Counteracted by Na+/K+-ATPase. Journal of Biological Chemistry, 292 (2). pp. 723-731. ISSN 0021-9258
Gaunt, HJ, Vasudev, NS orcid.org/0000-0001-8470-7481 and Beech, DJ (2016) Transient receptor potential canonical 4 and 5 proteins as targets in cancer therapeutics. European Biophysics Journal, 45 (7). pp. 611-620. ISSN 0175-7571
Naylor, J, Minard, A, Gaunt, HJ et al. (17 more authors) (2016) Natural and synthetic flavonoid modulation of TRPC5 channels. British Journal of Pharmacology, 173 (3). pp. 562-574. ISSN 0007-1188
Li, J, Bruns, A-F orcid.org/0000-0002-6970-4036, Hou, B et al. (18 more authors) (2015) Orai3 Surface Accumulation and Calcium Entry Evoked by Vascular Endothelial Growth Factor. Arteriosclerosis, Thrombosis, and Vascular Biology, 35 (9). pp. 1987-1994. ISSN 1079-5642
Akbulut, Y, Gaunt, HJ, Muraki, K et al. (12 more authors) (2015) (−)-Englerin A is a Potent and Selective Activator of TRPC4 and TRPC5 Calcium Channels. Angewandte Chemie International Edition, 54 (12). pp. 3787-3791. ISSN 1433-7851
Wilson, LA, McKeown, L, Tumova, S orcid.org/0000-0003-2044-4998 et al. (2 more authors) (2015) Expression of a long variant of CRACR2A that belongs to the Rab GTPase protein family in endothelial cells. Biochemical and Biophysical Research Communications, 456 (1). pp. 398-402. ISSN 0006-291X
Ye, M, Yang, W, Ainscough, JF et al. (11 more authors) (2014) TRPM2 channel deficiency prevents delayed cytosolic Zn²⁺ accumulation and CA1 pyramidal neuronal death after transient global ischemia. Cell Death and Disease, 5. e1541. ISSN 2041-4889
Li, J, Hou, B, Tumova, S orcid.org/0000-0003-2044-4998 et al. (25 more authors) (2014) Piezo1 integration of vascular architecture with physiological force. Nature, 515. pp. 279-282. ISSN 0028-0836
Cubbon, RM orcid.org/0000-0001-7844-3600, Yuldasheva, NY orcid.org/0000-0001-6213-6358, Viswambharan, H orcid.org/0000-0002-7616-5026 et al. (20 more authors) (2014) Restoring Akt1 activity in outgrowth endothelial cells from South Asian men rescues vascular reparative potential. Stem Cells, 32 (10). pp. 2714-2723. ISSN 1066-5099
Zou, J, Ainscough, JF, Yang, W et al. (6 more authors) (2013) A differential role of macrophage TRPM2 channels in Ca2+ signaling and cell death in early responses to H2O2. American Journal of Physiology: Cell Physiology, 305 (1). C61 - C69. ISSN 0363-6143
Sukumar, P orcid.org/0000-0002-3294-989X, Viswambharan, H orcid.org/0000-0002-7616-5026, Imrie, H orcid.org/0000-0002-1940-6604 et al. (14 more authors) (2013) Nox2 NADPH Oxidase Has a Critical Role in Insulin Resistance–Related Endothelial Cell Dysfunction. Diabetes, 62 (6). pp. 2130-2134. ISSN 0012-1797
Amer, MS, McKeown, L, Tumova, S et al. (14 more authors) (2013) Inhibition of endothelial cell Ca²⁺ entry and transient receptor potential channels by Sigma-1 receptor ligands. British Journal of Pharmacology, 168 (6). pp. 1445-1455. ISSN 0007-1188
Imrie, H orcid.org/0000-0002-1940-6604, Viswambharan, H orcid.org/0000-0002-7616-5026, Sukumar, P et al. (16 more authors) (2012) Novel Role of the IGF-1 Receptor in Endothelial Function and Repair: Studies in Endothelium-Targeted IGF-1 Receptor Transgenic Mice. Diabetes, 61 (9). pp. 2359-2368. ISSN 0012-1797
Li, J, McKeown, L orcid.org/0000-0003-2326-7595, Ojelabi, O et al. (5 more authors) (2011) Nanomolar potency and selectivity of a Ca 2+ release-activated Ca 2+ channel inhibitor against store-operated Ca 2+ entry and migration of vascular smooth muscle cells. British Journal of Pharmacology, 164 (2). pp. 382-393. ISSN 0007-1188
Abbas, A, Imrie, H orcid.org/0000-0002-1940-6604, Viswambharan, H orcid.org/0000-0002-7616-5026 et al. (14 more authors) (2011) The Insulin-Like Growth Factor-1 Receptor Is a Negative Regulator of Nitric Oxide Bioavailability and Insulin Sensitivity in the Endothelium. Diabetes, 60 (8). pp. 2169-2178. ISSN 0012-1797
Dedman, AM, Majeed, Y, Tumova, S orcid.org/0000-0003-2044-4998 et al. (8 more authors) (2011) TRPC1 transcript variants, inefficient nonsense-mediated decay and low up-frameshift-1 in vascular smooth muscle cells. BMC Molecular Biology, 12 (1). 30. ISSN 1471-2199
Cheong, A, Li, J, Sukumar, P orcid.org/0000-0002-3294-989X et al. (7 more authors) (2011) Potent suppression of vascular smooth muscle cell migration and human neointimal hyperplasia by KV1.3 channel blockers. Cardiovascular Research, 89 (2). pp. 282-289. ISSN 0008-6363
Ciurtin, C, Majeed, Y, Naylor, J et al. (4 more authors) (2010) TRPM3 channel stimulated by pregnenolone sulphate in synovial fibroblasts and negatively coupled to hyaluronan. BMC Musculoskeletal Disorders, 11 (1). 111. ISSN 1471-2474
Wong, C-O, Sukumar, P orcid.org/0000-0002-3294-989X, Beech, DJ et al. (1 more author) (2010) Nitric oxide lacks direct effect on TRPC5 channels but suppresses endogenous TRPC5-containing channels in endothelial cells. Pflügers Archiv - European Journal of Physiology, 460 (1). pp. 121-130. ISSN 0031-6768
Conference or Workshop Item
Dryn, DO, Melnyk, MI, Bon, RS et al. (2 more authors) (2022) Biophysical and kinetics properties of TRPC4 gating depend on its activation mode. In: Europhysiology 2022, 16-18 Sep 2022, Copenhagen, Denmark.
Cheng, C, Deivasikamani, V, Beech, DJ et al. (1 more author) (2019) Association of Piezo1 Variants With Hypertension in UK Biobank Participants. In: American Heart Association's 2019 Scientific Sessions, 16-19 Nov 2019, Philadelphia, USA.
Proceedings Paper
Evans, EL, Shi, J, Bettale, M et al. (2 more authors) (2019) Haematological Characterisation of Mice with Piezo1 Gain-Of-Function Mutation. In: Biophysical Journal. Biophysical Society, 63rd Anual Meeting, 02-06 Mar 2019, Baltimore, Maryland. Biophysical Society , 243A-243A.
Rode, B, Yuldasheva, NY orcid.org/0000-0001-6213-6358, Baxter, P et al. (3 more authors) (2016) Protective effects arising from inhibition of TRPC1/5 ion channel permeation in hypercholesterolaemic mice. In: Heart. BSCR Autumn 2016 - Cardiovascular Disease and Diabetes, 05-06 Sep 2016. BMJ Publishing Group , A6-A6.
Preprint
Cheng, CW orcid.org/0000-0002-2873-0828, Deivasikamani, V, Ludlow, MJ et al. (4 more authors) (2020) Genetic variants of PIEZO1 associate with COVID-19 fatality. [Preprint]