Nyambe-Silavwe, H and Williamson, G (2016) Polyphenol- and fibre-rich dried fruits with green tea attenuate starch-derived postprandial blood glucose and insulin: a randomised, controlled, single-blind, cross-over intervention. British Journal of Nutrition, 116 (3). pp. 443-450. ISSN 0007-1145
Abstract
Polyphenol- and fibre-rich foods (PFRF) have the potential to affect postprandial glycaemic responses by reducing glucose absorption, and thus decreasing the glycaemic response of foods when consumed together. A randomised, single-blind, cross-over study was conducted on sixteen healthy volunteers to test whether PFRF could attenuate postprandial blood glucose in healthy volunteers when added to a source of carbohydrate (starch in bread). This is the first study to examine the effects of a meal comprised of components to inhibit each stage of the biochemical pathway, leading up to the appearance of glucose in the blood. The volunteers were fasted and attended four visits: two control visits (bread, water, balancing sugars) and two test visits (single and double dose of PFRF) where they consumed bread, water and PFRF. Blood samples were collected at 0 (fasted), 15, 30, 45, 60, 90, 120, 150 and 180 min after consumption. The PFRF components were tested for α-amylase and α-glucosidase inhibitory potential in vitro. Plasma glucose was lower after consumption of both doses compared with controls: lower dose, change in mean incremental areas under the glucose curves (IAUC)=− 27·4 (SD 7·5) %, P< 0·001; higher dose, IAUC =− 49·0 (SD 15·3) %, P<0·001; insulin IAUC was also attenuated by − 46·9 (SD 13·4) %, P<0·01. Consistent with this, the polyphenol components of the PFRF inhibited α-amylase (green tea, strawberry, blackberry and blackcurrant) and α-glucosidase (green tea) activities in vitro. The PFRF have a pronounced and significant lowering effect on postprandial blood glucose and insulin response in humans, due in part to inhibition of α-amylase and α-glucosidase, as well as glucose transport.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © The Authors 2016. This is an author produced version of a paper published in British Journal of Nutrition. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | postprandial glucose, diabetes, α-amylase, α-glucosidase, polyphenols, fibre |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Environment (Leeds) > School of Food Science and Nutrition (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 23 May 2016 09:55 |
Last Modified: | 09 Dec 2016 21:29 |
Published Version: | http://dx.doi.org/10.1017/S0007114516002221 |
Status: | Published |
Publisher: | Cambridge University Press |
Identification Number: | 10.1017/S0007114516002221 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:99970 |