Synthesis of oxetane/azetidine containing spirocycles via the 1,3-dipolar cycloaddition reaction
Jones, B, Proud, M and Sridharan, V
(2016)
Synthesis of oxetane/azetidine containing spirocycles via the 1,3-dipolar cycloaddition reaction.
Tetrahedron Letters, 57 (25).
pp. 2811-2813.
ISSN 0040-4039
Abstract
Silver catalyzed 1,3-dipolar cycloaddition reactions between methyl 2-(oxetane/azetidine-3 ylidene) acetate as dipolarophiles and imines derived from –amino acid methyl esters, 2-aminomethyl pyridine and 2-aminomethyl pyrazine afforded oxetane/azetidine containing spirocycles in 40-77% yield. The use of 3-oxetanone used as the carbonyl compound thermal 1,3-dipolar cycloaddition reactions with secondary-amino acids or methyl esters resulted in oxetane spirocycles in 62-90% yield.
Metadata
Item Type:
Article
Authors/Creators:
Jones, B
Proud, M
Sridharan, V
Copyright, Publisher and Additional Information:
Crown Copyright (c) 2016. Published by Elsevier Ltd. All rights reserved. This is an author produced version of a paper published in Tetrahedron Letters. Uploaded in accordance with the publisher's self-archiving policy.
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