Gillott, RG, Willan, K, Kain, K orcid.org/0000-0002-9043-2637 et al. (2 more authors) (2017) South Asian ethnicity is associated with a lower prevalence of atrial fibrillation despite greater prevalence of established risk factors: a population-based study in Bradford Metropolitan District. EP Europace, 19 (3). pp. 356-363. ISSN 1099-5129
Abstract
Aims: Previous studies indicate that South Asians (SAs) may have a reduced risk of developing atrial fibrillation (AF) despite having a higher prevalence of traditional cardiovascular risk factors. This observational study was designed to explore the relative differences between SAs and Whites in a well-defined, multi-ethnic population with careful consideration of traditional cardiovascular risk factors that are thought to contribute to the development of AF. Methods and results: Anonymized data from 417 575 adults were sourced from primary care records within Bradford Metropolitan District, UK. Atrial fibrillation diagnosis was indicated by the presence on the AF Quality Outcomes Framework register. Self-reported ethnicity was mapped to census ethnic codes. The age-standardized prevalence rates of AF were calculated for comparison between the White and SA populations; our study sample presented relative proportions of 2.39 and 0.4%. Multivariable logistic regression analysis was performed to estimate the odds of developing AF given SA ethnicity. Adjustment for age, sex, and established risk factors found a 71% reduction in odds of AF in SAs when compared with Whites [odds ratio (OR): 0.29, 95% confidence interval (CI): 0.26–0.32]. When stratified by ethnicity, analyses revealed significantly different odds of AF for patients with diabetes; diabetes was not associated with the development of AF in the SA population (0.81, 95% CI: 0.63–1.05). Conclusion: This study, in a multi-ethnic population, presents ethnicity as a predictor of AF in which prevalence is significantly lower in SAs when compared with Whites. This is despite SAs having a higher frequency of established risk factors for the development of AF, such as ischaemic heart disease, heart failure, hypertension, and type 2 diabetes. These findings are consistent with previous literature and add weight to the need for further investigation, although this is the first study to investigate the differential associations of individual risk factors with development of AF.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | (c) 2016, The Author. Published on behalf of the European Society of Cardiology. All rights reserved. For permissions please email: journals.permissions@oup.com. This is a pre-copyedited, author-produced PDF of an article accepted for publication in EP-Europace following peer review. The version of record, 'Gillott, RG, Willan, K, Kain, K et al (2017) South Asian ethnicity is associated with a lower prevalence of atrial fibrillation despite greater prevalence of established risk factors: a population-based study in Bradford Metropolitan District. EP-Europace, 19 (3). pp. 356-363,' is available online at: https://doi.org/10.1093/europace/euw010 |
Keywords: | Atrial fibrillation; South Asian; White; Ethnicity; Prevalence; Risk factors |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM) > Clinical & Population Science Dept (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 19 May 2016 09:55 |
Last Modified: | 19 Jun 2020 09:44 |
Published Version: | https://doi.org/10.1093/europace/euw010 |
Status: | Published |
Publisher: | Oxford University Press (OUP) |
Identification Number: | 10.1093/europace/euw010 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:99738 |