Matthews, LC and Hanley, NA (2011) The stress of starvation: glucocorticoid restraint of beta cell development. Diabetologia, 54 (2). pp. 223-226. ISSN 0012-186X
Abstract
Developmental insults during gestation, such as under-nutrition, are known to restrict the number of beta cells that form in the fetal pancreas and are maintained in adulthood, leading to increased risk of type 2 diabetes. There are now substantial data indicating that glucocorticoids mediate this effect of under-nutrition on beta cell mass and that even at physiological levels they restrain fetal beta cell development in utero. There are emerging clues that this occurs downstream of endocrine commitment by neurogenin 3 but prior to terminal beta cell differentiation. Deciphering the precise mechanism will be important as it might unveil new pathways by which to manipulate beta cell mass that could be exploited as novel therapies for patients with diabetes.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | (c) The Author(s) 2010. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. |
Keywords: | Beta cell; Corticosterone; Cortisol; Development; Glucocorticoid; Glucocorticoid receptor; Human; Insulin; Mouse; Neurogenin 3; Pancreas; Under-nutrition |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Cancer and Pathology (LICAP) > Infection and Immunity (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 12 Mar 2019 09:38 |
Last Modified: | 12 Mar 2019 09:38 |
Status: | Published |
Publisher: | Springer Verlag |
Identification Number: | 10.1007/s00125-010-1963-x |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:99708 |