Barnard, A, Long, K, Martin, HL et al. (5 more authors) (2015) Selective and Potent Proteomimetic Inhibitors of Intracellular Protein-Protein Interactions. Angewandte Chemie, 127 (10). pp. 3003-3008. ISSN 0044-8249
Abstract
Inhibition of protein-protein interactions (PPIs) represents a major challenge in chemical biology and drug discovery. α-Helix mediated PPIs may be amenable to modulation using generic chemotypes, termed "proteomimetics", which can be assembled in a modular manner to reproduce the vectoral presentation of key side chains found on a helical motif from one partner within the PPI. In this work, it is demonstrated that by using a library of N-alkylated aromatic oligoamide helix mimetics, potent helix mimetics which reproduce their biophysical binding selectivity in a cellular context can be identified.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2015 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
Keywords: | Apoptose; Foldamere; Helikale Strukturen; Peptidomimetika; Protein‐Protein‐Wechselwirkungen |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Molecular and Cellular Biology (Leeds) The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemistry (Leeds) > Organic Chemistry (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 14 Sep 2016 09:29 |
Last Modified: | 14 Sep 2016 09:29 |
Published Version: | http://dx.doi.org/10.1002/ange.201410810 |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1002/ange.201410810 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:99696 |