Murnane, D, Ramachandran, V, Hammond, RB et al. (8 more authors) (2016) Blending Pre-formulation Metrics with Molecular Calculations to Facilitate Aerosol Product Formulation. In: Respiratory Drug Delivery 2016. Respiratory Drug Delivery, 17-21 Apr 2016, Phoenix, Arizona. RDD , pp. 79-88.
Abstract
In silico modeling using synthonic engineering provides a powerful tool to assist quality by design (QbD) strategies by facilitating the study of molecular forces of interaction between formulation components such as carrier particles and active pharmaceutical ingredients (APIs) in inhalation products. This article reports the outcomes of an inter-disciplinary study that combined computational molecular modeling and the measurement of interparticulate forces and rapid formulation pre-screening with the aim of achieving a priori formulation design and rapid verification through a material testing approach.
Metadata
Item Type: | Proceedings Paper |
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Authors/Creators: |
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Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemical & Process Engineering (Leeds) > Institute for Particle Science and Engineering (Leeds) |
Funding Information: | Funder Grant number Pfizer N/A |
Depositing User: | Symplectic Publications |
Date Deposited: | 13 May 2016 13:16 |
Last Modified: | 11 Apr 2017 03:11 |
Published Version: | http://www.rddonline.com/publications/articles/art... |
Status: | Published |
Publisher: | RDD |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:99546 |