Harrison, Eleanor, Dytham, Calvin orcid.org/0000-0002-4111-9484, Hall, James Peter John et al. (3 more authors) (2016) Rapid compensatory evolution promotes the survival of conjugative plasmids. Mobile genetic elements. e1179074.
Abstract
Conjugative plasmids play a vital role in bacterial adaptation through horizontal gene transfer. Explaining how plasmids persist in host populations however is difficult, given the high costs often associated with plasmid carriage. Compensatory evolution to ameliorate this cost can rescue plasmids from extinction. In a recently published study we showed that compensatory evolution repeatedly targeted the same bacterial regulatory system, GacA/GacS, in populations of plasmid-carrying bacteria evolving across a range of selective environments. Mutations in these genes arose rapidly and completely eliminated the cost of plasmid carriage. Here we extend our analysis using an individual based model to explore the dynamics of compensatory evolution in this system. We show that mutations which ameliorate the cost of plasmid carriage can prevent both the loss of plasmids from the population and the fixation of accessory traits on the bacterial chromosome. We discuss how dependent the outcome of compensatory evolution is on the strength and availability of such mutations and the rate at which beneficial accessory traits integrate on the host chromosome
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Biology (York) |
Depositing User: | Pure (York) |
Date Deposited: | 05 May 2016 14:45 |
Last Modified: | 08 Feb 2025 00:19 |
Published Version: | https://doi.org/10.1080/2159256X.2016.1179074 |
Status: | Published online |
Refereed: | Yes |
Identification Number: | 10.1080/2159256X.2016.1179074 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:99331 |
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Filename: Rapid_compensatory_evolution_promotes_the_survival_of_conjugative_plasmids_2.pdf
Description: Rapid compensatory evolution promotes the survival of conjugative plasmids-2