Liddon, John T R orcid.org/0000-0002-5287-9817, James, Michael J. orcid.org/0000-0003-2591-0046, Clarke, Aimee K. et al. (3 more authors) (2016) Catalyst-driven scaffold diversity:selective synthesis of spirocycles, carbazoles and quinolines from indolyl ynones. Chemistry : A European Journal. 8777–8780. ISSN 0947-6539
Abstract
Medicinally relevant spirocyclic indolenines, carbazoles and quinolines can each be directly synthesised selectively from common indolyl ynone starting materials by catalyst variation. The high yielding, divergent reactions all proceed via an initial dearomatising spirocyclisation reaction to generate an intermediate vinyl metal species which then rearranges selectively by careful choice of catalyst and reaction conditions.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2016, The publisher. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details |
Keywords: | carbazoles,catalysis,diversity,quinolines,spirocycles,Stereoisomerism,Spiro Compounds/chemical synthesis,Indoles/chemistry,Carbazoles/chemical synthesis,Mesylates/chemistry,Quinolines/chemical synthesis |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) |
Depositing User: | Pure (York) |
Date Deposited: | 17 May 2016 10:03 |
Last Modified: | 02 Apr 2025 23:07 |
Published Version: | https://doi.org/10.1002/chem.201601836 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1002/chem.201601836 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:99300 |
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