Balasubramanian, S.P. orcid.org/0000-0001-5953-2843, Brown, N.J. orcid.org/0000-0002-2100-1905 and Reed, M.W.R. (2002) Role of genetic polymorphisms in tumour angiogenesis. British Journal of Cancer, 87. pp. 1057-1065. ISSN 0007-0920
Abstract
Angiogenesis plays a crucial role in the development, growth and spread of solid tumours. Pro- and anti-angiogenic factors are abnormally expressed in tumours, influencing tumour angiogenesis, growth and progression. Polymorphisms in genes encoding angiogenic factors or their receptors may alter protein expression and/or activity. This article reviews the literature to determine the possible role of angiogenesis-related polymorphisms in cancer. Further research studies in this potentially crucial area of tumour biology are proposed.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2002 Cancer Research UK. From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/ |
Keywords: | Tumour angiogenesis; genetic polymorphism(s) |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > The Medical School (Sheffield) > Division of Genomic Medicine (Sheffield) > Department of Oncology and Metabolism (Sheffield) The University of Sheffield > Sheffield Teaching Hospitals |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 03 May 2016 10:38 |
Last Modified: | 03 May 2016 10:38 |
Published Version: | http://dx.doi.org/10.1038/sj.bjc.6600625 |
Status: | Published |
Publisher: | Cancer Research UK |
Refereed: | Yes |
Identification Number: | 10.1038/sj.bjc.6600625 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:99226 |
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