Kovar, H, Alonso, J, Aman, P et al. (34 more authors) (2012) The first European interdisciplinary Ewing sarcoma research summit. Frontiers in Oncology, 2. 54.
Abstract
The European Network for Cancer Research in Children and Adolescents (ENCCA) provides an interaction platform for stakeholders in research and care of children with cancer. Among ENCCA objectives is the establishment of biology-based prioritization mechanisms for the selection of innovative targets, drugs, and prognostic markers for validation in clinical trials. Specifically for sarcomas, there is a burning need for novel treatment options, since current chemotherapeutic treatment protocols have met their limits. This is most obvious for metastatic Ewing sarcoma (ES), where long term survival rates are still below 20%. Despite significant progress in our understanding of ES biology, clinical translation of promising laboratory results has not yet taken place due to fragmentation of research and lack of an institutionalized discussion forum. To fill this gap, ENCCA assembled 30 European expert scientists and five North American opinion leaders in December 2011 to exchange thoughts and discuss the state of the art in ES research and latest results from the bench, and to propose biological studies and novel promising therapeutics for the upcoming European EWING2008 and EWING2012 clinical trials.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2012 Kovar, Alonso, Aman, Aryee, Ban, Burchill, Burdach, De Alava, Delattre, Dirksen, Fourtouna, Fulda, Helman, Herrero-Martin, Hogendoorn, Kontny, Lawlor, Lessnick, Llombart-Bosch, Metzler, Moriggl, Niedan, Potratz, Redini, Richter, Riedmann, Rossig, Schäfer, Schwentner, Scotlandi, Sorensen, Staege, Tirode, Toretsky, Ventura, Eggert and Ladenstein. This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited. |
Keywords: | Ewing sarcoma; animal models; biomarkers; drug screen; epigenetics; genomics; prognosis; sarcomagenesis |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > Institute of Molecular Medicine (LIMM) (Leeds) > Section of Experimental Oncology (Leeds) The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Cancer and Pathology (LICAP) > Section of Experimental Oncology (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 11 Aug 2016 14:37 |
Last Modified: | 11 Aug 2016 14:37 |
Published Version: | http://dx.doi.org/10.3389/fonc.2012.00054 |
Status: | Published |
Publisher: | Frontiers Media |
Identification Number: | 10.3389/fonc.2012.00054 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:99131 |