Murphy, G., Knäuper, V., Atkinson, S. et al. (5 more authors) (2002) Matrix metalloproteinases in arthritic disease. Arthritis Research, 4 (Supp 3). S39-S49. ISSN 1465-9905
Abstract
The role of matrix metalloproteinases in the degradative events invoked in the cartilage and bone of arthritic joints has long been appreciated and attempts at the development of proteinase inhibitors as potential therapeutic agents have been made. However, the spectrum of these enzymes orchestrating connective tissue turnover and general biology is much larger than anticipated. Biochemical studies of the individual members of the matrix metalloproteinase family are now underway, ultimately leading to a more detailed understanding of the function of their domain structures and to defining their specific role in cellular systems and the way that they are regulated. Coupled with a more comprehensive and detailed study of proteinase expression in different cells of joint tissues during the progress of arthritic diseases, it will be possible for the future development and application of highly specific proteinase inhibitors to be directed at specific key cellular events.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2002 BioMed Cemtral Ltd. Reproduced in accordance with the publisher's self-archiving policy |
Keywords: | Arthritis, Rheumatoid; Humans; Matrix Metalloproteinases; Protein Structure, Tertiary |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Sheffield Teaching Hospitals |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 27 Apr 2016 09:10 |
Last Modified: | 27 Apr 2016 09:11 |
Published Version: | http://dx.doi.org/10.1186/ar572 |
Status: | Published |
Publisher: | BioMed Central |
Refereed: | Yes |
Identification Number: | 10.1186/ar572 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:99082 |