Lamoureux, F., Baud'huin, M., Duplomb, L. et al. (2 more authors) (2007) Proteoglycans: key partners in bone cell biology. BioEssays, 29 (8). pp. 758-771. ISSN 0265-9247
Abstract
The diversity of bone proteoglycan (PG) structure and localisation (pericellular, extracellular in the organic bone matrix) reflects a broad spectrum of biological functions within a unique tissue. PGs play important roles in organizing the bone extracellular matrix, taking part in the structuring of the tissue itself as active regulators of collagen fibrillogenesis. PGs also display selective patterns of reactivity with several constituents including cytokines and growth factors, such as transforming growth factor-β or osteoprotegerin thereby modulating their bio-availability and biological activity in the bone tissue. In this review, the complex PG composition in bone will be addressed together with the specific role played by PGs (or their GAGs chains) in bone biology, as regulatory molecules for bone resorption and their involvement in bone tumor development. These roles have been determined after modulation of PG expression or mutations in their corresponding genes, which revealed specific roles for these compounds in bone pathologies (e.g. perlecan or glypican-3 mutations observed respectively in chondrodysplasia or dysmorphic syndrome). Finally, the potential therapeutic interest of PGs is discussed based on recent data, more particularly on bone tumor-associated osteolysis as these molecules are involved both in bone resorption and tumor development.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2007 Wiley Periodicals, Inc. |
Keywords: | HEPARAN-SULFATE PROTEOGLYCANS; GROWTH-FACTOR-BETA; EXTRACELLULAR-MATRIX PROTEOGLYCANS; MARROW STROMAL CELLS; IN-VITRO; MULTIPLE-MYELOMA; OSTEOBLAST DIFFERENTIATION; OSTEOCLAST DIFFERENTIATION; COLLAGEN FIBRILLOGENESIS; SYNDECAN-1 EXPRESSION |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > The Medical School (Sheffield) > Division of Genomic Medicine (Sheffield) > Department of Oncology and Metabolism (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 25 Apr 2016 13:09 |
Last Modified: | 25 Apr 2016 13:46 |
Published Version: | http://dx.doi.org/10.1002/bies.20612 |
Status: | Published |
Publisher: | Wiley |
Refereed: | Yes |
Identification Number: | 10.1002/bies.20612 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:98249 |