Baud'huin, M., Lamoureuxa, F., Duplomba, L. et al. (2 more authors) (2007) RANKL, RANK, osteoprotegerin: key partners of osteoimmunology and vascular diseases. Cellular and Molecular Life Sciences, 64 (18). pp. 2334-2350. ISSN 1420-682X
Abstract
1997 saw the identification of a novel set of proteins within the tumor necrosis factor (TNF)/TNF receptor families that are required for the control of bone remodeling. Therefore, these receptors, receptor activator of nuclear factor kappa B (RANK), osteoprotegerin (OPG) and their ligand RANK ligand (RANKL) became the critical molecular triad controlling osteoclastogenesis and pathophysiologic bone remodeling. However, the establishment of the corresponding knock-out and transgenic mice revealed unexpected results, most particularly, the involvement of these factors in the vascular system and immunity. Thus, the OPG/RANK/RANKL molecular triad appears to be associated with vascular calcifications and plays a pivotal function in the development of the immune system through dendritic cells. OPG/RANK/RANKL thus constitute a molecular bridge spanning bone metabolism, vascular biology and immunity. This review summarizes recent knowledge of OPG/RANK/RANKL interactions and activities as well as the current evidence for their participation in osteoimmunology and vascular diseases. In fine, the targeting of the OPG/RANK/RANKL axis as novel therapeutic approaches will be discussed.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © Birkhuser Verlag, Basel, 2007. |
Keywords: | RANKL; osteoprotegerin; bone remodeling; osteoclast; osteolysis; osteoimmunology; cardiovascular disease; NF-KAPPA-B; TUMOR-NECROSIS-FACTOR; APOPTOSIS-INDUCING LIGAND; SOLUBLE RECEPTOR ACTIVATOR; REGULATES OSTEOCLAST DIFFERENTIATION; ENDOTHELIAL GROWTH-FACTOR; TRAIL-INDUCED APOPTOSIS; PROSTATE-CANCER CELLS; SMOOTH-MUSCLE-CELLS; BONE-MINERAL DENSITY |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > The Medical School (Sheffield) > Division of Genomic Medicine (Sheffield) > Department of Oncology and Metabolism (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 25 Apr 2016 13:38 |
Last Modified: | 05 Nov 2017 09:58 |
Published Version: | http://dx.doi.org/10.1007/s00018-007-7104-0 |
Status: | Published |
Publisher: | Springer Verlag |
Refereed: | Yes |
Identification Number: | 10.1007/s00018-007-7104-0 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:98238 |