Baud'huin, M., Duplomb, L., Velasco, C.R. et al. (3 more authors) (2007) Key roles of the OPG-RANK-RANKL system in bone oncology. Expert Review of Anticancer Therapy, 7 (2). pp. 221-232. ISSN 1473-7140
Abstract
Osteoprotegerin (OPG)–receptor activator of nuclear factor-κB (RANK) and RANK ligand (RANKL) have been identified as members of a ligand–receptor system that directly regulates osteoclast differentiation and osteolysis. RANKL may be a powerful inducer of bone resorption through its interaction with RANK, and OPG is a soluble decoy receptor that acts as a strong inhibitor of osteoclastic differentiation. Any dysregulation of their respective expression leads to pathological conditions. Furthermore, recent data demonstrate that the OPG–RANK–RANKL system modulates cancer cell migration, thus controlling the development of bone metastases. This review describes the most recent knowledge on the OPG–RANK–RANKL system, its involvement in bone oncology and the new therapeutic approaches based on this molecular triad.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2007 Taylor & Francis. |
Keywords: | bone; metastases; OPG; osteoblast; osteoclast; osteolysis; primary tumor; RANKL; secondary tumor; FACTOR-KAPPA-B; MEDIATES OSTEOCLAST DIFFERENTIATION; TRAIL-INDUCED APOPTOSIS; PROSTATE-CANCER CELLS; FORMATION IN-VITRO; RECEPTOR ACTIVATOR; MULTIPLE-MYELOMA; OSTEOPROTEGERIN OPG; BREAST-CANCER; POSTMENOPAUSAL WOMEN |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > The Medical School (Sheffield) > Division of Genomic Medicine (Sheffield) > Department of Oncology and Metabolism (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 25 Apr 2016 13:52 |
Last Modified: | 15 Nov 2016 19:28 |
Published Version: | http://dx.doi.org/10.1586/14737140.7.2.221 |
Status: | Published |
Publisher: | Taylor & Francis |
Refereed: | Yes |
Identification Number: | 10.1586/14737140.7.2.221 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:98229 |