Georges, S., Veiasco, C.R., Trichet, V. et al. (3 more authors) (2009) Proteases and bone remodelling. Cytokine & Growth Factor Reviews, 20 (1). pp. 29-41. ISSN 1359-6101
Abstract
Bone remodelling is regulated by osteogenic cells which act individually through cellular and molecular interaction. These interactions can be established either through a cell–cell contact, involving molecules of the integrin family, or by the release of many polypeptidic factors and/or their soluble receptor chains. Proteolytic shedding of membrane-associated proteins regulates the physiological activity of numerous proteins. Proteases located on the plasma membrane, either as transmembrane proteins or anchored to cell-surface molecules, serve as activators or inhibitors of different cellular and physiological processes. This review will focus on the role of the proteases implicated in bone remodelling either through the proteolytic degradation of the extracellular matrix or through their relations with osteogenic factors. Their implication in bone tumor progression will be also considered.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2008 Elsevier Ltd. All rights reserved. |
Keywords: | Protease; Bone remodelling; Cathepsin K; Metalloproteinases |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > The Medical School (Sheffield) > Division of Genomic Medicine (Sheffield) > Department of Oncology and Metabolism (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 05 May 2016 15:37 |
Last Modified: | 08 Nov 2016 19:19 |
Published Version: | http://dx.doi.org/10.1016/j.cytogfr.2008.11.005 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.cytogfr.2008.11.005 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:98213 |