Le Goff, B. and Heymann, D. orcid.org/0000-0001-7777-0669 (2011) Pharmacodynamics of bisphosphonates in arthritis. Expert Review of Clinical Pharmacology, 4 (5). pp. 633-641. ISSN 1751-2433
Abstract
Inflammatory arthritis is a group of autoimmune diseases characterized by chronic inflammation of the joints. Rheumatoid arthritis, the most common form of arthritis, is associated with local joint destruction and systemic bone loss. Osteoclasts, the only cells of the body able to resorbe bone, are key players in these two types of bone loss. Bisphosphonates are analogs of pyrophosphate that inhibit osteoclast action and bone resorption. They are indicated in pathology associated with excess resorption. Besides their effect on bone they also exhibit extra-osseous properties, acting on tumor cells, inflammation and angiogenesis. As a result, they have been trialed in the context of arthritis. It is now clear that they do not have any significant direct effect on disease activity or pain. If their indication in the prevention of glucocorticoid-induced osteoporosis is clear, any beneficial effects on bone erosions are still controversial but interesting preliminary results warrant further investigations.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2011 Taylor & Francis. This is an author produced version of a paper subsequently published in Expert Review of Clinical Pharmacology. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Animals; Bone Resorption; Clinical Trials as Topic; Diphosphonates; Humans; Osteoarthritis; Osteoclasts |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > The Medical School (Sheffield) > Division of Genomic Medicine (Sheffield) > Department of Oncology and Metabolism (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 14 Apr 2016 14:50 |
Last Modified: | 22 Apr 2016 21:25 |
Published Version: | http://dx.doi.org/10.1586/ecp.11.40 |
Status: | Published |
Publisher: | Taylor & Francis |
Identification Number: | 10.1586/ecp.11.40 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:98184 |