Picarda, G., Trichet, V., Teletchea, S. et al. (2 more authors) (2012) TRAIL receptor signaling and therapeutic option in bone tumors: the trap of the bone microenvironment. American Journal of Cancer Research, 2 (1). pp. 45-64. ISSN 2156-6976
Abstract
Tumor Necrosis Factor-Related Apoptosis Inducing Ligand (TRAIL/TNFSF10) has been reported to specifically induce malignant cell death being relatively nontoxic to normal cells. Since its identification 15 years ago, the antitumor activity and therapeutic value of TRAIL have been extensively studied. Five receptors quickly emerged, two of them being able to induce programmed cell death in tumor cells. This review takes a comprehensive look at this ligand and its receptors, and its potential role in primary bone tumors (osteosarcoma and Ewing's sarcoma) therapy. The main limit of clinical use of TRAIL being the innate or acquired resistance mechanisms, different possibilities to sensitize resistant cells are discussed in this review, together with the impact of bone microenvironment in the regulation of TRAIL activity.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | AJCR Copyright © 2012. Reproduced in accordance with the publisher's self-archiving policy. |
Keywords: | Tumor Necrosis Factor-Related Apoptosis Inducing Ligand; TRAIL/TNFSF10; receptor; signalingbone tumor; microenvironment |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > The Medical School (Sheffield) > Division of Genomic Medicine (Sheffield) > Department of Oncology and Metabolism (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 17 May 2016 12:34 |
Last Modified: | 17 May 2016 12:34 |
Status: | Published |
Publisher: | e-Century Publishing |
Refereed: | Yes |
Identification Number: | http://www.ajcr.us/ajcr0000088A.html |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:98179 |