TWELVES, C.J., DOBBS, N.A., CURNOW, A. et al. (5 more authors) (1994) A phase II, multicentre, UK study of vinorelbine in advanced breast cancer. British Journal of Cancer , 70 (5). pp. 990-993. ISSN 0007-0920
Abstract
Thirty-four evaluable patients were treated with vinorelbine, a novel, semisynthetic vinca alkaloid, as first-line chemotherapy for advanced breast cancer. They received vinorelbine 25 mg m-2 i.v. given weekly for a maximum of 16 cycles. Two patients achieved a complete remission and 15 a partial remission, giving a response rate of 17/34 (50%; 95% CI of 34-66%); median response duration was 5.8 months. The median progression-free interval was 4.4 months and median survival 9.9 months. Treatment was generally well tolerated. Fatigue was the most common side-effect. The main reason for dose adjustments was myelosuppression; 68% of patients had WHO grade 3 or 4 neutropenia and there was one death attributed to neutropenic sepsis. Nausea/vomiting and neuropathy were mild and alopecia was uncommon. This study confirms vinorelbine as a highly active, well-tolerated agent in advanced breast cancer worthy of evaluation in combination chemotherapy regimens.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 1994 Macmillan Press Ltd. Reproduced in accordance with the publisher's self-archiving policy. |
Keywords: | NAVELBINE |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > The Medical School (Sheffield) > Division of Genomic Medicine (Sheffield) > Department of Oncology and Metabolism (Sheffield) The University of Sheffield > Sheffield Teaching Hospitals |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 28 Sep 2016 12:43 |
Last Modified: | 28 Sep 2016 12:43 |
Published Version: | http://dx.doi.org/10.1038/bjc.1994.435 |
Status: | Published |
Publisher: | Nature Publishing Group |
Refereed: | Yes |
Identification Number: | 10.1038/bjc.1994.435 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:97854 |