Grimm, S.E. orcid.org/0000-0002-2175-7999, Dixon, S. and Stevens, J. (2013) Are we over-estimating the value of further research? A review of methods used to estimate uptake in population expected value of information analyses. Discussion Paper. HEDS Discussion Paper Series (13.15). Health Economics and Decision Science, School of Health and Related Research (ScHARR), University of Sheffield , Sheffield.
Abstract
Background: There is a lack of guidance on how population estimates should be obtained for expected value of information (EVI) analysis. We argue that disregarding uptake may lead to over-estimation of the population EVI (PEVI). Aims: To investigate how population estimates for PEVI analyses were obtained, whether they were adjusted by uptake and what methods were employed to obtain the uptake estimates. Methods: A literature search and review was conducted using the NHS Economic Evaluation Database (EED) and prior knowledge of relevant publications. Publications were excluded when they did not report PEVI estimates or were duplicates. Results: Out of 43 records resulting from the CRD search and 3 relevant publications that were known to us prior to this study, 29 studies were included. Out of these, 27 had not adjusted their population estimate by uptake levels. The remaining 2 studies had obtained their uptake estimates from uptake levels reported in trials and based on assumption. Only 5 studies acknowledged uncertainty associated with the population estimate used. Conclusion: Based on the result that very few PEVI studies had adjusted their population estimate by uptake and taking into account the large downward effect that uptake adjustments could have on the value of PEVI estimates, there is a need for discussion and further research around uptake adjustments in PEVI analyses.
Metadata
Item Type: | Monograph |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2013 The Authors. Reproduced in accordance with the publisher's self-archiving policy. |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Health and Related Research (Sheffield) > ScHARR - Sheffield Centre for Health and Related Research The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Health and Related Research (Sheffield) > Health Economics and Decision Science > HEDS Discussion Paper Series |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 19 Apr 2016 15:44 |
Last Modified: | 19 Apr 2016 15:52 |
Published Version: | http://www.sheffield.ac.uk/scharr/sections/heds/di... |
Status: | Published |
Publisher: | Health Economics and Decision Science, School of Health and Related Research (ScHARR), University of Sheffield |
Series Name: | HEDS Discussion Paper Series |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:97824 |