Duncan, EJ, Gluckman, PD and Dearden, PK (2014) Epigenetics, Plasticity, and Evolution: How do We Link Epigenetic Change to Phenotype? Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, 322 (4). pp. 208-220. ISSN 1552-5007
Abstract
Epigenetic mechanisms are proposed as an important way in which the genome responds to the environment. Epigenetic marks, including DNA methylation and Histone modifications, can be triggered by environmental effects, and lead to permanent changes in gene expression, affecting the phenotype of an organism. Epigenetic mechanisms have been proposed as key in plasticity, allowing environmental exposure to shape future gene expression. While we are beginning to understand how these mechanisms have roles in human biology and disease, we have little understanding of their roles and impacts on ecology and evolution. In this review, we discuss different types of epigenetic marks, their roles in gene expression and plasticity, methods for assaying epigenetic changes, and point out the future advances we require to understand fully the impact of this field.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2014 The Authors. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Biology (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 22 Jun 2016 08:19 |
Last Modified: | 13 May 2019 12:45 |
Published Version: | http://dx.doi.org/10.1002/jez.b.22571 |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1002/jez.b.22571 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:97707 |