Dai, J., Hensel, J., Wang, N. et al. (2 more authors) (2016) Mouse models for studying prostate cancer bone metastasis. BoneKEy Reports, 5. 777 . ISSN 2047-6396
Abstract
Once tumor cells metastasize to the bone, the prognosis for prostate cancer patients is generally very poor. The mechanisms involved in bone metastasis, however, remain elusive, because of lack of relevant animal models. In this manuscript, we describe step-by-step protocols for the xenograft mouse models that are currently used for studying prostate cancer bone metastasis. The different routes of tumor inoculation (intraosseous, intracardiac, intravenous and orthotopic) presented are useful for exploring the biology of bone metastasis.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2016 Nature Publishing Group. This is an author produced version of a paper subsequently published in BoneKEy Reports. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Bone cancer; Bone metastases |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > Department of Human Metabolism (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 21 Apr 2016 11:15 |
Last Modified: | 03 Nov 2017 01:26 |
Published Version: | https://dx.doi.org/10.1038/bonekey.2016.4 |
Status: | Published |
Publisher: | Nature Publishing Group |
Refereed: | Yes |
Identification Number: | 10.1038/bonekey.2016.4 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:97673 |