Justin, R., Tao, K., Román, S. et al. (10 more authors) (2016) Photoluminescent and superparamagnetic reduced graphene oxide-iron oxide quantum dots for dual-modality imaging, drug delivery and photothermal therapy. Carbon, 97. pp. 54-70. ISSN 0008-6223
Abstract
Reduced graphene oxide–iron oxide quantum dots (QDs) with intrinsic photoluminescent and superparamagnetic properties were synthesized through a green, hydrothermal method that simultaneously reduced and shattered graphene nanosheets to form the dots. The structure, morphology, properties and cell viability of these QDs were investigated. The QDs emitted violet light when excited at 320 nm, possessed no residual magnetization upon magnetic hysteresis tests, and had low cytotoxicity to healthy cells at low concentrations. The suitability of the QDs for fluorescent and magnetic resonance dual-modality imaging was shown by in vitro imaging with dermal fibroblast cells and T2 relaxation time. A drug could be loaded onto the surface of the QDs, with a loading ratio of drug to QD of 0.31:1. The drug achieved a steady but full release from the QDs over 8 h: these drug-loaded QDs could be manipulated by an external magnetic stimulation for targeted drug delivery. The potential for use as a cancer photothermal therapy was demonstrated by both a rapid, ∼50 °C temperature increase by a suspension of 100 μg ml−1 of QDs and the photothermal ablation of HeLa cells in vitro under near infrared irradiation. The stability of the MGQDs in fetal calf serum was shown to improve when an ionic drug was coated on the surface.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2015 Elsevier Ltd. All rights reserved. This is an author produced version of a paper subsequently published in Carbon. Uploaded in accordance with the publisher's self-archiving policy. Article available under the terms of the CC-BY-NC-ND licence (https://creativecommons.org/licenses/by-nc-nd/4.0/) |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Engineering (Sheffield) > Department of Electronic and Electrical Engineering (Sheffield) The University of Sheffield > Faculty of Engineering (Sheffield) > Department of Materials Science and Engineering (Sheffield) The University of Sheffield > Faculty of Science (Sheffield) > Department of Physics and Astronomy (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 08 Apr 2016 13:45 |
Last Modified: | 02 Jul 2016 07:59 |
Published Version: | http://dx.doi.org/10.1016/j.carbon.2015.06.070 |
Status: | Published |
Publisher: | Elsevier |
Refereed: | Yes |
Identification Number: | 10.1016/j.carbon.2015.06.070 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:97582 |