Fisher, Peter and Ungar, Daniel orcid.org/0000-0002-9852-6160 (2016) Bridging the Gap between Glycosylation and Vesicle Traffic. Frontiers in cell and developmental biology. 15. ISSN 2296-634X
Abstract
Glycosylation is recognized as a vitally important posttranslational modification. The structure of glycans that decorate proteins and lipids is largely dictated by biosynthetic reactions occurring in the Golgi apparatus. This biosynthesis relies on the relative distribution of glycosyltransferases and glycosidases, which is maintained by retrograde vesicle traffic between Golgi cisternae. Tethering of vesicles at the Golgi apparatus prior to fusion is regulated by Rab GTPases, coiled-coil tethers termed golgins and the multisubunit tethering complex known as the conserved oligomeric Golgi (COG) complex. In this review we discuss the mechanisms involved in vesicle tethering at the Golgi apparatus and highlight the importance of tethering in the context of glycan biosynthesis and a set of diseases known as congenital disorders of glycosylation.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | ©2016 Fisher and Ungar. |
Keywords: | Golgi apparatus, glycan processing, COG complex, Congenital disorders of glycosylation, vesicle tethering |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Biology (York) |
Funding Information: | Funder Grant number BBSRC (BIOTECHNOLOGY AND BIOLOGICAL SCIENCES RESEARCH COUNCIL) BB/M018237/1 BBSRC (BIOTECHNOLOGY AND BIOLOGICAL SCIENCES RESEARCH COUNCIL) BB/F006993/1 |
Depositing User: | Pure (York) |
Date Deposited: | 31 Mar 2016 11:46 |
Last Modified: | 04 Nov 2024 01:14 |
Published Version: | https://doi.org/10.3389/fcell.2016.00015 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.3389/fcell.2016.00015 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:97524 |