Transport Mechanism of a Glutamate Transporter Homologue GltPh

Abstract

Glutamate transporters are responsible for uptake of the neurotransmitter glutamate in mammalian central nervous systems. Their archaeal homologue GltPh, an aspartate transporter isolated from Pyrococcus horikoshii, has been the focus of extensive studies through crystallography, MD simulations and single-molecule FRET (smFRET). Here, we summarize the recent research progress on GltPh, in the hope of gaining some insights into the transport mechanism of this aspartate transporter.

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Item Type:	Article
Authors/Creators:	Ji, Y Postis, VLG https://orcid.org/0000-0001-9251-4567 Wang, Y Bartlam, M Goldman, A
Copyright, Publisher and Additional Information:	© 2016 The Author(s) This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution Licence 4.0 (CC BY).
Keywords:	Glutamate transporter; EAATs; GltPh; aspartate transporter; Na+ coupling; C1- conductance
Dates:	Published: 9 June 2016 Accepted: 30 March 2016
Institution:	The University of Leeds
Academic Units:	The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Biomedical Sciences (Leeds)
Funding Information:	Funder Grant number Royal Society WM120073 Wellcome Trust 091322/Z/10/Z BBSRC BB/M021610/1
Depositing User:	Symplectic Publications
Date Deposited:	06 May 2016 15:11
Last Modified:	12 Apr 2017 07:37
Published Version:	https://dx.doi.org/10.1042/BST20160055
Status:	Published
Publisher:	Portland Press
Identification Number:	10.1042/BST20160055
Open Archives Initiative ID (OAI ID):	oai:eprints.whiterose.ac.uk:97301

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Transport Mechanism of a Glutamate Transporter Homologue GltPh

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