Wang, J, Wang, F, Li, F et al. (4 more authors) (2016) A multifunctional poly(curcumin) nanomedicine for dual-modal targeted delivery, intracellular responsive release, dual-drug treatment and imaging of multidrug resistant cancer cells. Journal of Materials Chemistry B, 4 (17). pp. 2954-2962. ISSN 2050-750X
Abstract
A multifunctional anti-cancer nanomedicine based on a biotin-poly(ethylene glycol)-poly(curcumin-dithiodipropionic acid) (Biotin-PEG-PCDA) polymeric nanocarrier loaded with paclitaxel (PTX), magnetic nanoparticle (MNP) and quantum dot (QD) is developed. It combines advantageous properties of efficient targeted delivery and uptake (via biotin and MNP), intracellular responsive release (via cleavable PCDA polymer), fluorescence imaging (via QD) and combined PTX-curcumin dual-drug treatment, allowing for overcoming drug resistance mechanisms of model multidrug resistant breast cancer cells (MCF-7/ADR). The PTX/MNPs/QDs@Biotin-PEG-PCDA nanoparticles are highly stable under physiological conditions, but are quickly disassembled to release their drug load in the presence of 10 mM glutathione (GSH). The nanoparticles show high uptake by tumour cells from a combined effect of magnet targeting and biotin receptor-mediated internalization. Moreover, curcumin, an intracellularly cleaved product of PCDA, can effectively downregulate the expression of drug efflux transporters such as P-glycoprotein (P-gp) to increase PTX accumulation within target cancer cells, thereby enhancing PTX induced cytotoxicity and therapeutic efficacy against MCF-7/ADR cells. Taken together, this novel tumour targeting and traceable multifunctional nanomedicine is highly effective against model MDR cancer at the cellular level.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © The Royal Society of Chemistry 2016. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. |
Keywords: | multifunctional nanomedicine; polycurcumin; Targeted cancer therapy; multidrug resistance; theranotic nanoparticle; cell uptake |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemistry (Leeds) > Inorganic Chemistry (Leeds) |
Funding Information: | Funder Grant number European Research Council 331281 EU - European Union 331281 EU - European Union 331281 |
Depositing User: | Symplectic Publications |
Date Deposited: | 25 May 2016 13:54 |
Last Modified: | 23 Jun 2023 22:02 |
Published Version: | http://dx.doi.org/10.1039/c5tb02450a |
Status: | Published |
Publisher: | Royal Society of Chemistry |
Identification Number: | 10.1039/c5tb02450a |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:97149 |