Fagan, R.P. orcid.org/0000-0002-8704-4828 and Fairweather, N.F. (2014) Biogenesis and functions of bacterial S-layers. Nature Reviews Microbiology, 12. 3. pp. 211-222. ISSN 1740-1526
Abstract
The outer surface of many archaea and bacteria is coated with a proteinaceous surface layer (known as an S-layer), which is formed by the self-assembly of monomeric proteins into a regularly spaced, two-dimensional array. Bacteria possess dedicated pathways for the secretion and anchoring of the S-layer to the cell wall, and some Gram-positive species have large S-layer-associated gene families. S-layers have important roles in growth and survival, and their many functions include the maintenance of cell integrity, enzyme display and, in pathogens and commensals, interaction with the host and its immune system. In this Review, we discuss our current knowledge of S-layer and related proteins, including their structures, mechanisms of secretion and anchoring and their diverse functions.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2014 Nature Publishing. This is an author produced version of a paper subsequently published in Nature Reviews Microbiology. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Bacterial physiology; Bacterial secretion; Bacterial structural biology; Cellular microbiology |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > School of Biosciences (Sheffield) > Department of Molecular Biology and Biotechnology (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 08 Apr 2016 10:19 |
Last Modified: | 23 Mar 2018 01:56 |
Status: | Published |
Publisher: | Nature Publishing Group |
Refereed: | Yes |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:97080 |