Lewis, C.E. and Hughes, R. (2007) Inflammation and breast cancer. Microenvironmental factors regulating macrophage function in breast tumours: hypoxia and angiopoietin-2. Breast Cancer Research, 9 (3). p. 209. ISSN 1465-5411
Abstract
Considerable evidence has now accumulated for tumour-associated macrophages stimulating key aspects of tumour progression, including the proliferation, survival and metastasis of tumour cells, tumour angiogenesis and suppression of the anti-tumour functions of other immune effectors at the tumour site. Tumour micro-environmental factors such as hypoxia have profound, direct effects on these cells, stimulating many of their pro-tumour functions. Hypoxia also does so indirectly by stimulating the release of the cytokine angiopoietin-2 from tumour cells and tumour blood vessels. This in turn then recruits Tie-2-expressing monocytes into tumours from the bloodstream and inhibits their production of anti-apoptotic and anti-angiogenic cytokines.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2007 BioMed Central Ltd |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > The Medical School (Sheffield) > Department of Infection & Immunity |
Depositing User: | Sheffield Import |
Date Deposited: | 09 Oct 2009 08:51 |
Last Modified: | 09 Oct 2009 08:51 |
Published Version: | http://breast-cancer-research.com/content/9/3/209 |
Status: | Published |
Publisher: | BioMed Central |
Identification Number: | 10.1186/bcr1679 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:9694 |