Bingle, L., Richards, R.J., Fox, B. et al. (3 more authors) (1997) Susceptibility of lung epithelium to neutrophil elastase: protection by native inhibitors. Mediators of Inflammation, 6 (5-6). pp. 345-354. ISSN 0962-9351
Abstract
The development of emphysema is thought to be due to an imbalance of proteases (especially neutrophil elastase [NE]) and antiproteases with loosening of the respiratory epithelium as an early event. We investigated the effect of NE on respiratory epithelial cell adherence in vitro , in the presence of varying concentrations and combinations of native inhibitors, α-1-proteinase inhibitor (PI) and secretory leukoprotease inhibitor (SLPI). SLPI was two to 12 times more effective than PI at preventing the effects of NE, especially when enzyme:inhibitor ratios were almost equivalent. Even when the concentration of SLPI was only 10% of the total (as in normal peripheral lung secretions), it gave greater protection than PI alone. This suggests that SLPI plays an important role in controlling neutrophil elastaseinduced inflammation and tissue damage.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 1997 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
Keywords: | alveolar; bronchiolar; epithelium; matrix; elastase; antiprotease; SECRETORY LEUKOPROTEASE INHIBITOR; ALVEOLAR TYPE-II; LEUKOCYTE ELASTASE; ALPHA-1-PROTEINASE INHIBITOR; PROTEINASE-INHIBITORS; XENOBIOTIC METABOLISM; BRONCHIAL INHIBITOR; SERINE PROTEINASES; CYSTIC-FIBROSIS; LINING FLUID |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Clinical Dentistry (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 22 Mar 2016 16:53 |
Last Modified: | 22 Mar 2016 17:02 |
Published Version: | http://dx.doi.org/10.1080/09629359791488 |
Status: | Published |
Publisher: | Hindawi Publishing Corporation |
Refereed: | Yes |
Identification Number: | 10.1080/09629359791488 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:96786 |