Wan, T, Stylios, GK, Giannoudi, M et al. (1 more author) (2015) Investigating a new drug delivery nano composite membrane system based on PVA/PCL and PVA/HA(PEG) for the controlled release of biopharmaceuticals for bone infections. Injury, 46. S39-S43. ISSN 0020-1383
Abstract
The capability for sustained and gradual release of pharmaceuticals is a major requirement in the development of a guided antimicrobial bacterial control system for clinical applications. In this study, PVA gels with varying constituents that were manufactured via a refreeze/thawing route, were found to have excellent potential for antimicrobial delivery for bone infections. Cefuroxime Sodium with poly(ethylene glycol) was incorporated into 2 delivery systems poly(e-caprolactone) (PCL) and hydroxyapatite (HA), by a modified emulsion process. Our results indicate that the Cefuroxime Sodium released from poly(e-caprolactone) in PVA was tailored to a sustained release over more than 45 days, while the release from hydroxyapatite PVA reach burst maximum after 20 days. These PVA hydrogel-systems were also capable of controlled and sustained release of other biopharmaceuticals.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Keywords: | drug delivery; poly(e-caprolactone); PVA hydrogels; bone infections; controlled delivery; nano composite; nano membrane |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Institute of Rheumatology & Musculoskeletal Medicine (LIRMM) (Leeds) > Orthopaedics (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 27 May 2016 15:52 |
Last Modified: | 27 May 2016 15:52 |
Published Version: | https://dx.doi.org/10.1016/S0020-1383(15)30053-X |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/S0020-1383(15)30053-X |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:96617 |