Blundell, JE, Finlayson, G, Gibbons, C et al. (2 more authors) (2015) The biology of appetite control: Do resting metabolic rate and fat-free mass drive energy intake? PHYSIOLOGY & BEHAVIOR, 152 (B). pp. 473-478. ISSN 0031-9384
Abstract
The prevailing model of homeostatic appetite control envisages two major inputs; signals from adipose tissue and from peptide hormones in the gastrointestinal tract. This model is based on the presumed major influence of adipose tissue on food intake. However, recent studies have indicated that in obese people fat-free mass (FFM) is strongly positively associated with daily energy intake and with meal size. This effect has been replicated in several independent groups varying in cultural and ethnic backgrounds, and appears to be a robust phenomenon. In contrast fat mass (FM) is weakly, or mildly negatively associated with food intake in obese people. In addition resting metabolic rate (RMR), a major component of total daily energy expenditure, is also associated with food intake. This effect has been replicated in different groups and is robust. This action is consistent with the proposal that energy requirements — reflected in RMR (and other aspects of energy expenditure) constitute a biological drive to eat. Consistent with its storage function, FM has a strong inhibitory effect on food intake in lean subjects, but this effect appears to weaken dramatically as adipose tissue increases. This formulation can account for several features of the development and maintenance of obesity and provides an alternative, and transparent, approach to the biology of appetite control.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2015 Published by Elsevier Inc. This is an author produced version of a paper published in Physiology and Behavior. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Energy intake; Resting metabolic rate; Fat-free mass; Fat mass; Energy balance |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Psychology (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 23 Mar 2016 14:04 |
Last Modified: | 02 Jun 2016 10:27 |
Published Version: | http://dx.doi.org/10.1016/j.physbeh.2015.05.031 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.physbeh.2015.05.031 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:96553 |