Peckham, D orcid.org/0000-0001-7723-1868, Watson, A, Pollard, K et al. (2 more authors) (2002) Predictors of desaturation during formal hypoxic challenge in adult patients with cystic fibrosis. Journal of Cystic Fibrosis, 1 (4). pp. 281-286. ISSN 1569-1993
Abstract
Assessment of the potential risk of in flight hypoxaemia in patients with cystic fibrosis is often based on a hypoxic challenge where individuals have saturations and/or blood gases taken before and after inspiring 15% normobaric oxygen. The aim of this study was to see if routine clinical measurements could predict the outcome of this test. This was a prospective study comparing the modified 6-min walking test, lung function, body mass index, Northern (N) and Shwachman–Kulczycki (SK) scores with a hypoxic challenge (flight test) in 69 adults attending the Leeds regional CF Unit. Although, there was a significant correlation between post flight test PaO2 and N score (P=0.003), SK score (P=0.002), FVC % predicted (P=0.01), FEV1 % predicted (P=0.002), resting saturations (P<0.001), 6 min saturation on walking test (P<0.001) and baseline PaO2 (P<0.001), no single parameter could accurately predict all patients who desaturated during the flight test. No individual clinical parameter appears to fully predict the need for in flight oxygen but patients most at risk appear to have either a low FEV1 (<60%), high N score (>13) or low baseline PaO2 (<10.5 kPa).
Metadata
Item Type: | Article |
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Authors/Creators: |
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Keywords: | Cystic fibrosis; Flight; Hypoxic challenge; Exercise test |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > Institute of Molecular Medicine (LIMM) (Leeds) > Section of Translational Medicine (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 13 Jul 2016 15:20 |
Last Modified: | 13 Jul 2016 15:20 |
Published Version: | http://dx.doi.org/10.1016/S1569-1993(02)00100-5 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/S1569-1993(02)00100-5 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:96095 |