King, MT, Costa, DSJ, Aaronson, NK et al. (12 more authors) (2016) QLU-C10D: a health state classification system for a multi-attribute utility measure based on the EORTC QLQ-C30. Quality of Life Research, 25 (3). pp. 625-636. ISSN 0962-9343
Abstract
Purpose: To derive a health state classification system (HSCS) from the cancer-specific quality of life questionnaire, the EORTC QLQ-C30, as the basis for a multi-attribute utility instrument. Methods: The conceptual model for the HSCS was based on the established domain structure of the QLQ-C30. Several criteria were considered to select a subset of dimensions and items for the HSCS. Expert opinion and patient input informed a priori selection of key dimensions. Psychometric criteria were assessed via secondary analysis of a pooled dataset comprising HRQOL and clinical data from 2616 patients from eight countries and a range of primary cancer sites, disease stages, and treatments. We used confirmatory factor analysis (CFA) to assess the conceptual model’s robustness and generalisability. We assessed item floor effects (>75 % observations at lowest score), disordered item response thresholds, coverage of the latent variable and differential item function using Rasch analysis. We calculated effect sizes for known group comparisons based on disease stage and responsiveness to change. Seventy-nine cancer patients assessed the relative importance of items within dimensions. Results: CFA supported the conceptual model and its generalisability across primary cancer sites. After considering all criteria, 12 items were selected representing 10 dimensions: physical functioning (mobility), role functioning, social functioning, emotional functioning, pain, fatigue, sleep, appetite, nausea, bowel problems. Conclusions: The HSCS created from QLQ-C30 items is known as the EORTC Quality of Life Utility Measure-Core 10 dimensions (QLU-C10D). The next phase of the QLU-C10D’s development involves valuation studies, currently planned or being conducted across the globe.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2016, Springer International Publishing Switzerland. This is a post-peer-review, pre-copyedit version of an article published in Quality of Life Research. The final authenticated version is available online at: https://doi.org/10.1007/s11136-015-1217-y. Uploaded in accordance with the publisher's self-archiving policy. |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Cancer and Pathology (LICAP) > Patient Centred Outcomes Research |
Depositing User: | Symplectic Publications |
Date Deposited: | 10 Mar 2016 11:08 |
Last Modified: | 21 Nov 2018 15:25 |
Published Version: | http://dx.doi.org/10.1007/s11136-015-1217-y |
Status: | Published |
Publisher: | Springer |
Identification Number: | 10.1007/s11136-015-1217-y |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:96034 |