Huf, G., Coutinho, E.S.F., Adams, C.E. et al. (11 more authors) (2003) Rapid tranquillisation for agitated patients in emergency psychiatric rooms: a randomised trial of midazolam versus haloperidol plus promethazine. BMJ, 327 (7417). pp. 708-711. ISSN 0959-8138
Abstract
OBJECTIVE: To compare two widely used drug treatments for people with aggression or agitation due to mental illness.
DESIGN: Pragmatic, randomised clinical trial.
SETTING: Three psychiatric emergency rooms in Rio de Janeiro, Brazil.
SUBJECTS: 301 aggressive or agitated people.
INTERVENTIONS: Open treatment with intramuscular midazolam or intramuscular haloperidol plus promethazine.
MAIN OUTCOME MEASURES: Patients tranquil or sedated at 20 minutes. Secondary outcomes: patients tranquil or asleep by 40, 60, and 120 minutes; restrained or given extra drugs within 2 hours; severe adverse events; another episode of agitation or aggression; needing extra visits from doctor during first 24 hours; overall antipsychotic load in first 24 hours; and not discharged by two weeks.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2003 BMJ Publishing Group Ltd. |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Health Sciences (Leeds) > Academic Unit of Psychiatry and Behavioural Sciences (Leeds) |
Depositing User: | Sherpa Assistant |
Date Deposited: | 13 Mar 2006 |
Last Modified: | 27 Oct 2016 01:26 |
Published Version: | http://bmj.com/cgi/content/full/327/7417/708 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1136/bmj.327.7417.708 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:959 |